Customizing nano-chitosan for sustainable drug delivery
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PMC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, the various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review article
Açıklama
Anahtar Kelimeler
Chitosan Polymer, Composite Hydrogels, Cross-Linkers, Drug Delivery, Hydrogels
Kaynak
Journal of controlled release : official journal of the Controlled Release Society
WoS Q DeÄŸeri
Q1
Scopus Q DeÄŸeri
Q1
Cilt
Sayı
Künye
Saeedi M, Vahidi O, Moghbeli M, Ahmadi S, Asadnia M, Akhavan O, Seidi F, Rabiee M, Saeb MR, Webster TJ, Varma RS, Sharifi E, Zarrabi A, Rabiee N. Customizing nano-chitosan for sustainable drug delivery. J Control Release. 2022 Jul 29:S0168-3659(22)00473-4. doi: 10.1016/j.jconrel.2022.07.038. Epub ahead of print. PMID: 35914615.
