Customizing nano-chitosan for sustainable drug delivery

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorMostafa Saeedi 1, Omid Vahidi 1, Mohammadreza Moghbeli 1, Sepideh Ahmadi 2, Mohsen Asadnia 3, Omid Akhavan 4, Farzad Seidi 5, Mohammad Rabiee 6, Mohammad Reza Saeb 7, Thomas J Webster 8, Rajender S Varma 9, Esmaeel Sharifi 10, Ali Zarrabi 11, Navid Rabiee 12 Affiliations collapse
dc.contributor.authorSaeedi, Mostafa
dc.contributor.authorVahidi, Omid
dc.contributor.authorMoghbeli, Mohammadreza
dc.contributor.authorAhmadi, Sepideh
dc.contributor.authorAsadnia, Mohsen
dc.contributor.authorAkhavan, Omid
dc.contributor.authorSeidi, Farzad
dc.contributor.authorRabiee, Mohammad
dc.contributor.authorSaeb, Mohammad Reza
dc.contributor.authorWebster, Thomas J.
dc.contributor.authorZarrabi, Ali
dc.contributor.authorRabiee, Navid
dc.contributor.authorVarma, Rajender S.
dc.contributor.authorSharifi, Esmaeel
dc.date.accessioned2022-08-03T13:50:06Z
dc.date.available2022-08-03T13:50:06Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractChitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, the various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review articleen_US
dc.identifier.citationSaeedi M, Vahidi O, Moghbeli M, Ahmadi S, Asadnia M, Akhavan O, Seidi F, Rabiee M, Saeb MR, Webster TJ, Varma RS, Sharifi E, Zarrabi A, Rabiee N. Customizing nano-chitosan for sustainable drug delivery. J Control Release. 2022 Jul 29:S0168-3659(22)00473-4. doi: 10.1016/j.jconrel.2022.07.038. Epub ahead of print. PMID: 35914615.en_US
dc.identifier.doi10.1016/j.jconrel.2022.07.038en_US
dc.identifier.issn0168-3659en_US
dc.identifier.pmid35914615en_US
dc.identifier.scopus2-s2.0-85136110063en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1016/j.jconrel.2022.07.038
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3065
dc.identifier.wosWOS:000865587300002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherPMCen_US
dc.relation.ispartofJournal of controlled release : official journal of the Controlled Release Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosan Polymeren_US
dc.subjectComposite Hydrogelsen_US
dc.subjectCross-Linkersen_US
dc.subjectDrug Deliveryen_US
dc.subjectHydrogelsen_US
dc.titleCustomizing nano-chitosan for sustainable drug deliveryen_US
dc.typeReview Articleen_US

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