Effects of intrathecai verapamil on cerebral vasospasm in experimental rat study
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil, METHODS: A total of 24 Sprague-Davvley rats were randomly divided into the following 3 groups: group 1 (sham), group 2 (subarachnoid hemorrhage), and group 3 {verapamil). A double hemorrhage method was used. Group 2 did not receive any treatment. Verapamil (Eporon, Hem Ilac, Turkey) at a dose of 1000 mu g/kg was given intrathecally to group 3 rats. The animals were euthanized on day 7 of the procedure. Arterial wall thickness and lumen diameter in the basilar arterial cross-sectional areas, endothelin-1 serum level, oxidative stress index, and apoptosis were measured in all groups. RESULTS: In the verapamil group, wall thickness, endothelin-1 level, oxidative stress index, and apoptosis were found to be significantly lower than the subarachnoid hemorrhage group, but the lumen diameter was found to be greater, Intrathecal verapamil was found to decrease vasospasm parameters and apoptosis and increase the antioxidant and antiapoptotic pathways. CONCLUSIONS: Our findings suggest that intrathecal verapamil can prevent vasospasnt oxidative stress, and apoptosis after experimental subarachnoid hemorrhage.
Açıklama
16th World Congress of Neurosurgery of the World-Federation-of-Neurosurgical-Societies (WFNS) -- AUG 20-25, 2017 -- Istanbul, TURKEY
Anahtar Kelimeler
Aneurysm, Apoptosis, Endothelin-1, Intrathecal Verapamil, Oxidative Stress, Subarachnoid Hemorrhage, Vasospasm
Kaynak
World Neurosurgery
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
127
Sayı
Künye
Akkaya, E., Evran, Ş., Çalış, F., Çevik, S., Hanımoğlu, H., Seyithanoğlu, M. H., ... & Hatiboğlu, M. A. (2019). Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study. World neurosurgery, 127, e1104-e1111.
