Effects of intrathecai verapamil on cerebral vasospasm in experimental rat study

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dc.authorscopusidSerdar Çevik / 56516611400
dc.authorwosidSerdar Çevik / G-7161-2018
dc.contributor.authorAkkaya, Enes
dc.contributor.authorEvran, Sevket
dc.contributor.authorCalis, Fatih
dc.contributor.authorÇevik, Serdar
dc.contributor.authorHanimoglu, Hakan
dc.contributor.authorSeyithanoglu, Mehmet Hakan
dc.contributor.authorKatar, Salim
dc.contributor.authorKaratas, Ersin
dc.contributor.authorKocyigit, Abdurrahim
dc.contributor.authorSaglam, Mustafa Yasin
dc.contributor.authorHatiboglu, Mustafa Aziz
dc.contributor.authorKaynar, Mehmet Yasar
dc.date.accessioned2020-08-30T20:06:45Z
dc.date.available2020-08-30T20:06:45Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Anestezi Bölümüen_US
dc.description16th World Congress of Neurosurgery of the World-Federation-of-Neurosurgical-Societies (WFNS) -- AUG 20-25, 2017 -- Istanbul, TURKEYen_US
dc.description.abstractBACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil, METHODS: A total of 24 Sprague-Davvley rats were randomly divided into the following 3 groups: group 1 (sham), group 2 (subarachnoid hemorrhage), and group 3 {verapamil). A double hemorrhage method was used. Group 2 did not receive any treatment. Verapamil (Eporon, Hem Ilac, Turkey) at a dose of 1000 mu g/kg was given intrathecally to group 3 rats. The animals were euthanized on day 7 of the procedure. Arterial wall thickness and lumen diameter in the basilar arterial cross-sectional areas, endothelin-1 serum level, oxidative stress index, and apoptosis were measured in all groups. RESULTS: In the verapamil group, wall thickness, endothelin-1 level, oxidative stress index, and apoptosis were found to be significantly lower than the subarachnoid hemorrhage group, but the lumen diameter was found to be greater, Intrathecal verapamil was found to decrease vasospasm parameters and apoptosis and increase the antioxidant and antiapoptotic pathways. CONCLUSIONS: Our findings suggest that intrathecal verapamil can prevent vasospasnt oxidative stress, and apoptosis after experimental subarachnoid hemorrhage.en_US
dc.description.sponsorshipWorld Federat Neurosurg Socen_US
dc.description.sponsorshipBezmialem Vakif University FundBezmialem Vakif University [3.2015/40]en_US
dc.description.sponsorshipThis work was supported by the Bezmialem Vakif University Fund (Project Number: 3.2015/40).en_US
dc.identifier.citationAkkaya, E., Evran, Ş., Çalış, F., Çevik, S., Hanımoğlu, H., Seyithanoğlu, M. H., ... & Hatiboğlu, M. A. (2019). Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study. World neurosurgery, 127, e1104-e1111.en_US
dc.identifier.doi10.1016/j.wneu.2019.04.050en_US
dc.identifier.endpageE1111en_US
dc.identifier.issn1878-8750en_US
dc.identifier.issn1878-8769en_US
dc.identifier.pmid30980985en_US
dc.identifier.scopus2-s2.0-85065244393en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE1104en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2019.04.050
dc.identifier.urihttps://hdl.handle.net/20.500.12713/612
dc.identifier.volume127en_US
dc.identifier.wosWOS:000473128300136en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇevik, Serdaren_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAneurysmen_US
dc.subjectApoptosisen_US
dc.subjectEndothelin-1en_US
dc.subjectIntrathecal Verapamilen_US
dc.subjectOxidative Stressen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectVasospasmen_US
dc.titleEffects of intrathecai verapamil on cerebral vasospasm in experimental rat studyen_US
dc.typeConference Objecten_US

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