Fluorescein-guided resection of intramedullary spinal cord tumors: results from a preliminary, multicentric, retrospective study

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dc.authoridMustafa Kemal Hamamcıoğlu / 0000-0003-1960-8182en_US
dc.authoridTalat Kırış / 0000-0002-2985-3758
dc.authoridMehmet Osman Akçakaya / 0000-0001-8617-202X
dc.authorscopusidMehmet Osman Akçakaya / 57241760900
dc.authorscopusidTalat Kırış / 6602747157
dc.authorscopusidMustafa Kemal Hamamcıoğlu / 6506296756
dc.authorwosidMehmet Osman Akçakaya / HTG-8644-2023
dc.authorwosidTalat Kırış / AAP-4665-2020
dc.authorwosidMustafa Kemal Hamamcıoğlu / A-3520-2019
dc.contributor.authorAcerbi, Francesco
dc.contributor.authorCavallo, Claudio
dc.contributor.authorSchebesch, Karl-Michael
dc.contributor.authorAkçakaya, Mehmet Osman
dc.contributor.authorde Laurentis, Camilla
dc.contributor.authorHamamcıoğlu, Mustafa Kemal
dc.contributor.authorBroggi, Morgan
dc.contributor.authorBrawanski, Alexander
dc.contributor.authorFalco, Jacopo
dc.contributor.authorCordella, Roberto
dc.contributor.authorFerroli, Paolo
dc.contributor.authorKırış, Talat
dc.contributor.authorHoehne, Julius
dc.date.accessioned2020-08-30T20:07:59Z
dc.date.available2020-08-30T20:07:59Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBACKGROUND: Intramedullary spinal cord tumors (IMSCTs) are rare, heterogenous lesions that are usually enhanced on preoperative magnetic resonance imaging (MRI) because of a damaged blood-brain barrier. Sodium fluorescein is a dye that accumulates in areas of the central nervous system with a damaged BBB. Given the pattern of MRI contrast enhancement of the majority of IMSCTs, the use of this fluorescent tracer could improve tumor visualization and quality of resection. In this article, we present the first experience with the application of fluorescein-guided technique for surgical removal of IMSCTs. METHODS: Eleven patients (6 men, 5 women; mean age, 50.1 years), harboring 5 ependymomas, 3 hemangio-blastomas, 1 astrocytoma, 1 pilocytic astrocytoma, and 1 glioneuronal tumor forming rosettes were included. Sodium fluorescein (5 mg/kg) was injected immediately after patient intubation. Tumors were removed with microsurgical technique and standard neurophysiological monitoring, under YELLOW 560 filter (Pentero 900) visualization. Surgical reports were reviewed regarding usefulness and grade of fluorescein staining. Postoperative MRI was performed within 72 hours after surgery, and postoperative clinical outcome was registered. RESULTS: No adverse events were registered. Fluorescent staining was reported in 9 of 11 cases (82%), all of them enhancing on preoperative MRI (100% of ependymomas, 100% of pilocytic astrocytomas, 100% of hemangioblastomas). No fluorescence was reported in 1 astrocytoma and 1 glioneuronal tumor-forming rosette. Intraoperative fluorescence was considered helpful for tumor resection in 9 of 11 cases (82%). Gross total resection was obtained in 8 of 11 cases (72.7%). CONCLUSIONS: Our results suggest that fluorescein-guided surgery is a safe and effective technique that can be used during the surgical resection of IMSCTs presenting with contrast-enhancement on preoperative MRI.en_US
dc.identifier.citationAcerbi, F., Cavallo, C., Schebesch, K.-M., Akçakaya, M. O., de Laurentis, C., Hamamcioglu, M. K., … Höhne, J. (2017). Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study. World Neurosurgery, 108, 603–609. https://doi.org/10.1016/j.wneu.2017.09.061en_US
dc.identifier.doi10.1016/j.wneu.2017.09.061en_US
dc.identifier.endpage609en_US
dc.identifier.issn1878-8750en_US
dc.identifier.issn1878-8769en_US
dc.identifier.pmid28935546en_US
dc.identifier.scopus2-s2.0-85030844481en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2017.09.061
dc.identifier.urihttps://hdl.handle.net/20.500.12713/865
dc.identifier.volume108en_US
dc.identifier.wosWOS:000415874900080en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkçakaya, Mehmet Osmanen_US
dc.institutionauthorHamamcıoğlu, Mustafa Kemalen_US
dc.institutionauthorKırış, Talaten_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntramedullary Spinal Cord Tumoren_US
dc.subjectResectionen_US
dc.subjectSodium Fluoresceinen_US
dc.subjectYellow 560 Filteren_US
dc.titleFluorescein-guided resection of intramedullary spinal cord tumors: results from a preliminary, multicentric, retrospective studyen_US
dc.typeArticleen_US

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