Aggressive clinicopathological course of myeloma with t(3;16) (q21;q22) cytogenetic abnormality

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dc.authoridSüreyya Bozkurt / 0000-0002-1765-9894en_US
dc.authorscopusidSüreyya Bozkurt / 55540860700
dc.authorwosidSüreyya Bozkurt / AAP-1146-2020
dc.contributor.authorBozkurt, Süreyya
dc.contributor.authorOkay, Mufide
dc.contributor.authorHaznedaroğlu, İbrahim
dc.date.accessioned2020-08-30T20:07:10Z
dc.date.available2020-08-30T20:07:10Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMultiple myeloma (MM) is a heterogeneous disease and patients present with a wide variety of cytogenetic anomalies reflecting the nature of the disease [1]. The aim of this letter is to report a rare karyotypic abnormality with an aggressive clinical course of MM. A 56-year-old male patient was admitted to the neurosurgery clinic with dorsal shoulder pain and inability to walk in April 2011. He underwent thoracic and lumbar spinal magnetic resonance imaging. Laminectomy was performed on the patient upon detecting masses at the levels of the first and seventh thoracic vertebrae. The patient was referred to our center when he was determined to have “lymphoma” based on the first evaluation 63 of his biopsy material. The specimen was then reevaluated in our center. A high-grade hematopoietic neoplasia was detected. Immunophenotypic findings suggested neoplasia with plasma cell origin. Immunohistochemically, neoplastic cells were positive for CD38, MUM-1, and kappa and negative for lambda. The karyotype of the patient was identified as 44,X,-Y,del(1) (p13p35),+der(1),t(3;16)(q21;q22),-4,-13,-14,+mar[8]/46,XY[42] (Figure 1).en_US
dc.identifier.citationBozkurt, S., Okay, M., & Haznedaroglu, I. (2019). Aggressive Clinicopathological Course of Myeloma with t (3; 16)(q21; q22) Cytogenetic Abnormality. Turk J Haematol, 36, 162-3.en_US
dc.identifier.doi10.4274/tjh.galenos.2018.2018.0049en_US
dc.identifier.endpage63en_US
dc.identifier.issn1300-7777en_US
dc.identifier.issn1308-5263en_US
dc.identifier.issue1en_US
dc.identifier.pmid29726398en_US
dc.identifier.scopus2-s2.0-85061132625en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage62en_US
dc.identifier.trdizinid353603en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2018.2018.0049
dc.identifier.urihttps://hdl.handle.net/20.500.12713/709
dc.identifier.volume36en_US
dc.identifier.wosWOS:000458334600018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozkurt, Süreyyaen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultiple Myelomaen_US
dc.subjectRare Translocationsen_US
dc.subjectCytogenetic Abnormalityen_US
dc.titleAggressive clinicopathological course of myeloma with t(3;16) (q21;q22) cytogenetic abnormalityen_US
dc.typeLetteren_US

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