COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group

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dc.authoridMurat Sütçü / 0000-0002-2078-9796en_US
dc.authoridEmine Manolya Kara / 0000-0001-6234-7024
dc.authorscopusidMurat Sütçü / 55499199300
dc.authorscopusidEmine Manolya Kara / 57213122996
dc.authorwosidMurat Sütçü / AAR-5212-2020
dc.authorwosidEmine Manolya Kara / AGI-2212-2022
dc.contributor.authorYılmaz Çiftdoğan, Dilek
dc.contributor.authorEkemen Keleş, Yıldız
dc.contributor.authorŞirvan Çetin, Benhur
dc.contributor.authorDalgıç Karabulut, Nazan
dc.contributor.authorSütçü, Murat
dc.contributor.authorKara, Emine Manolya
dc.date.accessioned2022-02-11T12:36:59Z
dc.date.available2022-02-11T12:36:59Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractMultisystemic inflammatory syndrome (MIS-C) diagnosis remains difficult because the clinical features overlap with Kawasaki disease (KD). The study aims to highlight the clinical and laboratory features and outcomes of patients with MISC whose clinical manifestations overlap with or without KD. This study is a retrospective analysis of a case series designed for patients aged 1 month to 18 years in 28 hospitals between November 1, 2020, and June 9, 2021. Patient demographics, complaints, laboratory results, echocardiographic results, system involvement, and outcomes were recorded. A total of 614 patients were enrolled; the median age was 7.4 years (interquartile range (IQR) 3.9-12 years). A total of 277 (45.1%) patients with MIS-C had manifestations that overlapped with KD, including 92 (33.3%) patients with complete KD and 185 (66.7%) with incomplete KD. Lymphocyte and platelet counts were significantly lower in patients with MISC, overlapped with KD (lymphocyte count 1080 vs. 1280 cells × ?L, p = 0.028; platelet count 166 vs. 216 cells × 103/?L, p < 0.001). The median serum procalcitonin levels were statistically higher in patients overlapped with KD (3.18 vs. 1.68 µg/L, p = 0.001). Coronary artery dilatation was statistically significant in patients with overlap with KD (13.4% vs. 6.8%, p = 0.007), while myocarditis was significantly more common in patients without overlap with KD features (2.6% vs 7.4%, p = 0.009). The association between clinical and laboratory findings and overlap with KD was investigated. Age > 12 years reduced the risk of overlap with KD by 66% (p < 0.001, 95% CI 0.217-0.550), lethargy increased the risk of overlap with KD by 2.6-fold (p = 0.011, 95% CI 1.244-5.439), and each unit more albumin (g/dl) reduced the risk of overlap with KD by 60% (p < 0.001, 95% CI 0.298-0.559).Conclusion: Almost half of the patients with MISC had clinical features that overlapped with KD; in particular, incomplete KD was present. The median age was lower in patients with KD-like features. Lymphocyte and platelet counts were lower, and ferritin and procalcitonin levels were significantly higher in patients with overlap with KD. What is Known: • In some cases of MIS-C, the clinical symptoms overlap with Kawasaki disease. • Compared to Kawasaki disease, lymphopenia was an independent predictor of MIS-C. What is New: • Half of the patients had clinical features that overlapped with Kawasaki disease. • In patients whose clinical features overlapped with KD, procalcitonin levels were almost 15 times higher than normal. • Lethargy increased the risk of overlap with KD by 2.6-fold in MIS-C patients. • Transient bradycardia was noted in approximately 10% of our patients after initiation of treatment.en_US
dc.identifier.citationYilmaz Ciftdogan D, Ekemen Keles Y, Cetin BS, Dalgic Karabulut N, Emiroglu M, Bagci Z, Buyukcam A, Erdeniz EH, Arga G, Yesil E, Cakici O, Karbuz A, Sahbudak Bal Z, Kara SS, Ozer A, Metin Akcan O, Elmas Bozdemir S, Anil AB, Uygun H, Kilic O, Hancerli Torun S, Umit Z, Sutcu M, Ozgokce Ozmen B, Karaoglu Asrak H, Alkan G, Kara Aksay A, Ugur C, Birbilen AZ, Bursal Duramaz B, Akyuz Ozkan E, Burakay O, Yildirim Arslan S, Karadag Oncel E, Celik SF, Kilic AO, Ozen S, Sarikaya R, Demirkol D, Arslan G, Turel O, Sert A, Sari E, Orbak Z, Sahin IO, Varan C, Akturk H, Tuter Oz SK, Durak F, Oflaz MB, Kara M, Karpuz D, Talip Petmezci M, Hatipoglu N, Oncel S, Turgut M, Elmali F, Somer A, Kuyucu N, Dinleyici EC, Kurugöl Z, Ciftci E, Kara A. COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group. Eur J Pediatr. 2022 Feb 7:1–13.en_US
dc.identifier.doi10.1007/s00431-022-04390-2en_US
dc.identifier.endpage13en_US
dc.identifier.issn0340-6199en_US
dc.identifier.issn1432-1076en_US
dc.identifier.pmid35129668en_US
dc.identifier.scopus2-s2.0-85124325518en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-022-04390-2
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2483
dc.identifier.volume7en_US
dc.identifier.wosWOS:000752164700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSütçü, Murat
dc.institutionauthorKara, Emine Manolya
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEur J Pediatren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectChildrenen_US
dc.subjectKawasaki Diseaseen_US
dc.subjectMIS-Cen_US
dc.titleCOVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study groupen_US
dc.typeArticleen_US

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