Serum neprilysin levels are elevated in preeclampsia
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.
Açıklama
Anahtar Kelimeler
Blood Pressure, Endopeptidase, Enkephalinase, Natriuretic Peptides, Neutral Endopeptidase
Kaynak
Taiwanese Journal of Obstetrics and Gynecology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Tuten N., Malik E., Gok K., Hamzaoglu K., Makul M., Oner Y.O., Bulut H., Tuten A. & Guralp O. (2021) Serum neprilysin levels are elevated in preeclampsia. Taiwanese Journal of Obstetrics and Gynecology.
