Serum neprilysin levels are elevated in preeclampsia

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorTüten, Nevin
dc.contributor.authorMalik, Eduard
dc.contributor.authorGök, Koray
dc.contributor.authorHamzaoğlu, Kübra
dc.contributor.authorMakul, Melike
dc.contributor.authorÖner, Yahya Özgün
dc.contributor.authorBulut, Huri
dc.contributor.authorTüten, Abdullah
dc.contributor.authorGüralp, Onur Şahin
dc.date.accessioned2021-08-07T07:16:48Z
dc.date.available2021-08-07T07:16:48Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 ± 65.30 pg/mL vs. 187.75 ± 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age-matched control group (228.84 ± 67.26 pg/mL vs. 186.14 ± 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 ± 63.85 pg/mL vs. 189.29 ± 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia.en_US
dc.identifier.citationTuten N., Malik E., Gok K., Hamzaoglu K., Makul M., Oner Y.O., Bulut H., Tuten A. & Guralp O. (2021) Serum neprilysin levels are elevated in preeclampsia. Taiwanese Journal of Obstetrics and Gynecology.en_US
dc.identifier.doi10.1016/j.tjog.2021.07.015en_US
dc.identifier.issn1028-4559en_US
dc.identifier.pmid34507663en_US
dc.identifier.scopus2-s2.0-85111341033en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tjog.2021.07.015
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1974
dc.identifier.wosWOS:000696939600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofTaiwanese Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood Pressureen_US
dc.subjectEndopeptidaseen_US
dc.subjectEnkephalinaseen_US
dc.subjectNatriuretic Peptidesen_US
dc.subjectNeutral Endopeptidaseen_US
dc.titleSerum neprilysin levels are elevated in preeclampsiaen_US
dc.typeArticleen_US

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