Correlation between endometriomas volume and Raman spectra. Attempting to use Raman spectroscopy in the diagnosis of endometrioma
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The formation of the uterus lining, i.e. the endometrium, outside the uterus (ex. in the abdominal cavity, ovaries, or anywhere in the body) is called endometriosis. The presence of endometrial tissue present in the ovaries, thickens after menstruation, leading to menstrual-like bleeding and to the formation of chocolate cyst (Endometrioma) because of the accumulation of old, brown blood in the ovary. It is still unknown, what triggers the development of endometrioma. However, it leads to excessive bleeding during menstrual periods or abnormal bleeding between periods and infertility. Endometriosis is often first diagnosed in those who seek medical attention for infertility. Therefore, new markers of endometrioma as well as new methods of its diagnosis are sought. In this study we used Raman spectra of serum collected from 50 healthy women and 50 women suffering from endometriosis. The obtained Raman data were used in multivariate analysis to determine the Raman range, which can be used for endometrioma diagnostics. Partial Least Square (PLS), Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA) showed, that it is possible to distinguish between the serum collected from healthy and un-healthy women using the Raman range between 800 cm?1 and 1800 cm?1 and between 2956 cm?1 and 2840 cm?1, while the first range corresponds to the fingerprint region and the second one to lipids vibrations. Consequently, the Pearson correlation test showed a significant positive correlation between values of lipid intensity in Raman spectra and volume of endometriomas. Summarizing, Raman spectroscopy can be a helpful tool in endometrioma diagnosis and the lipid vibrations are candidates for being a spectroscopic marker of the disease being studied. © 2022 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Correlation, Endometriosis;, Hierarchical Cluster Analysis, Partial Least Square, Principal Component Analysis, Raman Spectroscopy
Kaynak
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
274
Sayı
Künye
Guleken, Z., Bulut, H., Bulut, B., Paja, W., Parlinska-Wojtan, M., & Depciuch, J. (2022). Correlation between endometriomas volume and raman spectra. attempting to use raman spectroscopy in the diagnosis of endometrioma. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 274 doi:10.1016/j.saa.2022.121119
