Correlation between endometriomas volume and Raman spectra. Attempting to use Raman spectroscopy in the diagnosis of endometrioma

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dc.authoridHuri Bulut / 0000-0003-2706-9625
dc.authorscopusidHuri Bulut / 57185264300
dc.authorscopusidBerk Bulut / 24465134400
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.authorwosidBerk Bulut / IAE-6700-2023
dc.contributor.authorGüleken, Z.
dc.contributor.authorBulut, Huri
dc.contributor.authorBulut, Berk
dc.contributor.authorPaja, W.
dc.contributor.authorParlinska-Wojtan, M.
dc.contributor.authorDepciuch, J.
dc.date.accessioned2022-03-23T12:25:03Z
dc.date.available2022-03-23T12:25:03Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe formation of the uterus lining, i.e. the endometrium, outside the uterus (ex. in the abdominal cavity, ovaries, or anywhere in the body) is called endometriosis. The presence of endometrial tissue present in the ovaries, thickens after menstruation, leading to menstrual-like bleeding and to the formation of chocolate cyst (Endometrioma) because of the accumulation of old, brown blood in the ovary. It is still unknown, what triggers the development of endometrioma. However, it leads to excessive bleeding during menstrual periods or abnormal bleeding between periods and infertility. Endometriosis is often first diagnosed in those who seek medical attention for infertility. Therefore, new markers of endometrioma as well as new methods of its diagnosis are sought. In this study we used Raman spectra of serum collected from 50 healthy women and 50 women suffering from endometriosis. The obtained Raman data were used in multivariate analysis to determine the Raman range, which can be used for endometrioma diagnostics. Partial Least Square (PLS), Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA) showed, that it is possible to distinguish between the serum collected from healthy and un-healthy women using the Raman range between 800 cm?1 and 1800 cm?1 and between 2956 cm?1 and 2840 cm?1, while the first range corresponds to the fingerprint region and the second one to lipids vibrations. Consequently, the Pearson correlation test showed a significant positive correlation between values of lipid intensity in Raman spectra and volume of endometriomas. Summarizing, Raman spectroscopy can be a helpful tool in endometrioma diagnosis and the lipid vibrations are candidates for being a spectroscopic marker of the disease being studied. © 2022 Elsevier B.V.en_US
dc.identifier.citationGuleken, Z., Bulut, H., Bulut, B., Paja, W., Parlinska-Wojtan, M., & Depciuch, J. (2022). Correlation between endometriomas volume and raman spectra. attempting to use raman spectroscopy in the diagnosis of endometrioma. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 274 doi:10.1016/j.saa.2022.121119en_US
dc.identifier.doi10.1016/j.saa.2022.121119en_US
dc.identifier.issn1386-1425en_US
dc.identifier.pmid35305519en_US
dc.identifier.scopus2-s2.0-85126373393en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.saa.2022.121119
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2579
dc.identifier.volume274en_US
dc.identifier.wosWOS:000788848800015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Huri
dc.institutionauthorBulut, Berk
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorrelationen_US
dc.subjectEndometriosis;en_US
dc.subjectHierarchical Cluster Analysisen_US
dc.subjectPartial Least Squareen_US
dc.subjectPrincipal Component Analysisen_US
dc.subjectRaman Spectroscopyen_US
dc.titleCorrelation between endometriomas volume and Raman spectra. Attempting to use Raman spectroscopy in the diagnosis of endometriomaen_US
dc.typeArticleen_US

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