The role of endobronchial ultrasonography elastography in the diagnosis of hilar and mediastinal lymph nodes

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dc.authoridKoç, Aysu Sinem/0000-0001-5402-6730
dc.authoridEyhan Gül, Şule/0000-0002-7162-2611
dc.authoridDemirkol, Baris/0000-0001-5585-3842
dc.authoridBaydili, Kursad Nuri/0000-0002-2785-0406
dc.authorwosidKoç, Aysu Sinem/GQH-6513-2022
dc.authorwosidEyhan Gül, Şule/GOV-3362-2022
dc.authorwosidDemirkol, Baris/GRX-2022-2022
dc.authorwosidAkgun, Elife/ABC-4144-2020
dc.authorwosidBaydili, Kursad Nuri/HJA-0675-2022
dc.contributor.authorDemirkol, Baris
dc.contributor.authorTanriverdi, Elif
dc.contributor.authorGul, Sule
dc.contributor.authorKoc, Aysu Sinem
dc.contributor.authorAkgun, Elife
dc.contributor.authorYardimci, Aytuel Hande
dc.contributor.authorBaydili, Kursad Nuri
dc.date.accessioned2024-05-19T14:41:09Z
dc.date.available2024-05-19T14:41:09Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground/aim: Endobronchial ultrasonography (EBUS) is a minimally invasive diagnostic tool in the diagnosis of mediastinal lymph nodes (LNs) and has sonographic features. We aimed to investigate the diagnostic accuracy of EBUS elastography, which evaluates tissue compressibility integrated into EBUS, on malignant vs. benign mediastinal-hilar LNs.Materials and methods: A single-center, prospective study was conducted at the University of Health Sciences Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital between 01/10/2019 and 15/11/2019. The features of 219 LNs evaluated by thoracic computed tomography (CT), positron emission tomography (PET)/CT, EBUS sonography and EBUS elastography were recorded. The LNs sampled by EBUS-guided fine needle aspiration were classified according to EBUS elastography color distribution findings as follows: type 1, predominantly nonblue (green, yellow, and red); type 2, part blue, part nonblue; type 3, predominantly blue. The strain ratio (SR) was calculated based on normal tissue with the relevant region.Results: The average age of 131 patients included in the study was 55.86 & PLUSMN; 13 years, 76 (58%) were male. Two hundred and nineteen lymph nodes were sampled from different stations. Pathological diagnosis of 75 (34.2%) LNs was malignant, the rest was benign. When EBUS B-mode findings and pathological results were compared, sensitivity was 65.33%, specificity 63.19%, positive predictive value (PPV) 48%, negative predictive value (NPV) 77.8%, and diagnostic yield (DY) 64%. When the pathological diagnoses and EBUS elastography findings were compared, while type 1 LNs were considered to be benign and type 3 LNs malignant, sensitivity 94.12%, specificity 86.54%, PPV 82.1%, NPV 95.7%, and DY 89.5%. SR of malignant LNs was significantly higher than benign LNs (p < 0.001). When the classification according to color scale and SR were compared, no difference was found in DY (p = 0.155).Conclusion: The diagnostic accuracy of EBUS elastography is high enough to distinguish malignant LN from benign ones with the SR option. When compared with EBUS-B mode sonographic findings, it was found to have a higher diagnostic yield.en_US
dc.identifier.doi10.55730/1300-0144.5634
dc.identifier.endpage720en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid37476908en_US
dc.identifier.scopus2-s2.0-85163652383en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage712en_US
dc.identifier.trdizinid1191043en_US
dc.identifier.urihttps://doi.org10.55730/1300-0144.5634
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1191043
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5070
dc.identifier.volume53en_US
dc.identifier.wosWOS:001022334700011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectElastographyen_US
dc.subjectEndobronchial Ultrasonographyen_US
dc.subjectLymph Nodeen_US
dc.subjectMediastinumen_US
dc.subjectStrain Ratioen_US
dc.titleThe role of endobronchial ultrasonography elastography in the diagnosis of hilar and mediastinal lymph nodesen_US
dc.typeArticleen_US

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