Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies
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Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal Society of Chemistry
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, we report the synthesis, characterisation and preliminary biological evaluation of two novel silver(I) complexes of type [AgL2](NO3)3 (3 and 4) with ionic N-donor benzimidazoles. The complexes have been synthesized by the reaction of 1.5 equivalents of silver nitrate and N-donor benzimidazoles containing an imidazolium core at the 2-position (1 and 2) in ethanol. The X-ray analysis of 4 shows that it has two free imidazolium cores and the charge is balanced with three nitrate anions. A study by the combination of NMR, IR, LC-MS and elemental analysis techniques also suggests that the complexes have this structure both in the solid-state and solution. The complexes are highly soluble and stable in water. Cytotoxicity evaluation against four cancerous human cells and one non-cancerous human cell revealed that the complexes have no significant anti-growth effect. However, the complexes showed a remarkable antimicrobial effect at normalized minimum inhibitory concentrations (normalized MICs) in the range of 33–268 ?M against a panel of microorganisms consisting of Gram-negative and Gram-positive bacteria, and fungi.
Açıklama
Anahtar Kelimeler
Kaynak
Dalton Transactions
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
Karataş, M. O., Özdemir, N., Sarıman, M., Günal, S., Ulukaya, E., & Özdemir, İ. (2021). Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies. Dalton transactions (Cambridge, England : 2003), 10.1039/d1dt02008k. Advance online publication. https://doi.org/10.1039/d1dt02008k
