Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridMelda Sarıman / 0000-0003-0898-529X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidMelda Sarıman / 57191042731
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidMelda Sarıman / ABB-8877-2021
dc.contributor.authorKarataş, Mert Olgun
dc.contributor.authorÖzdemir, Namık
dc.contributor.authorSarıman, Melda
dc.contributor.authorGünal, Selami
dc.contributor.authorUlukaya, Engin
dc.contributor.authorÖzdemir, İsmail
dc.date.accessioned2021-08-09T08:34:22Z
dc.date.available2021-08-09T08:34:22Z
dc.date.issued2021en_US
dc.departmentISU, Rektörlük, Uygulama ve Araştırma Merkezleri, Moleküler Kanser Uygulama ve Araştırma Merkezien_US
dc.description.abstractHerein, we report the synthesis, characterisation and preliminary biological evaluation of two novel silver(I) complexes of type [AgL2](NO3)3 (3 and 4) with ionic N-donor benzimidazoles. The complexes have been synthesized by the reaction of 1.5 equivalents of silver nitrate and N-donor benzimidazoles containing an imidazolium core at the 2-position (1 and 2) in ethanol. The X-ray analysis of 4 shows that it has two free imidazolium cores and the charge is balanced with three nitrate anions. A study by the combination of NMR, IR, LC-MS and elemental analysis techniques also suggests that the complexes have this structure both in the solid-state and solution. The complexes are highly soluble and stable in water. Cytotoxicity evaluation against four cancerous human cells and one non-cancerous human cell revealed that the complexes have no significant anti-growth effect. However, the complexes showed a remarkable antimicrobial effect at normalized minimum inhibitory concentrations (normalized MICs) in the range of 33–268 ?M against a panel of microorganisms consisting of Gram-negative and Gram-positive bacteria, and fungi.en_US
dc.identifier.citationKarataş, M. O., Özdemir, N., Sarıman, M., Günal, S., Ulukaya, E., & Özdemir, İ. (2021). Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies. Dalton transactions (Cambridge, England : 2003), 10.1039/d1dt02008k. Advance online publication. https://doi.org/10.1039/d1dt02008ken_US
dc.identifier.doi10.1039/d1dt02008ken_US
dc.identifier.pmid34355725en_US
dc.identifier.scopus2-s2.0-85113601876en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1039/d1dt02008k
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1984
dc.identifier.wosWOS:000681720500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSarıman, Melda
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofDalton Transactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleWater-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studiesen_US
dc.typeArticleen_US

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