Anti-Acanthamoebic effects of silver-conjugated tetrazole nanoparticle
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Tetrazoles are five-membered ring aromatic heterocyclic molecules that consist of one carbon and four nitrogen atoms. Several tetrazole-based drugs have shown promising activities against bacteria, fungi, asthma, cancer, hypertension etc. The overall aim of this study was to determine anti-Acanthamoebic properties of tetrazoles and tetrazole-conjugated silver nanoparticles. Tetrazole-conjugated silver nanoparticles were synthesized and confirmed using ultraviolet–visible spectrometry, Dynamic light scattering, and Fourier-transform infrared spectroscopy. Using amoebicidal, encystment, and excystment assays, the findings revealed that tetrazoles exhibited antiamoebic properties and these effects were enhanced when conjugated with silver nanoparticles. Importantly, conjugation with silver nanoparticles inhibited parasite-mediated human cell death in vitro, as measured by lactate dehydrogenase release, but it reduced toxic effects of drugs alone on human cells. Overall, these results showed clearly that tetrazoles exhibit potent antiamoebic properties which can be enhanced by conjugation with silver nanoparticles and these potential in the rational development of therapeutic interventions against parasitic infections such as keratitis and granulomatous amoebic encephalitis due to pathogenic Acanthamoeba. © 2024 Elsevier Inc.
Açıklama
Anahtar Kelimeler
Drugs, Infections, Treatment, Parasites, Management
Kaynak
Experimental Parasitology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
265
Sayı
Künye
Anwar, A., Fatima, I., Khan, K. M., Daalah, M., Alawfi, B. S., Khan, N. A., & Anwar, A. (2024). Anti-Acanthamoebic effects of silver-conjugated tetrazole nanoparticle. Experimental Parasitology, 265, 108827.
