Anti-Acanthamoebic effects of silver-conjugated tetrazole nanoparticle

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dc.authorscopusidNaveed Ahmed Khan / 7401797675
dc.authorwosidNaveed Ahmed Khan / FXL-5617-2022
dc.contributor.authorAnwar, Areeba
dc.contributor.authorFatima, Itrat
dc.contributor.authorKhan, Khalid Mohammed
dc.contributor.authorDaalah, Meshal
dc.contributor.authorAlawfi, Bader S.
dc.contributor.authorKhan, Naveed Ahmed
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2025-04-18T07:49:09Z
dc.date.available2025-04-18T07:49:09Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractTetrazoles are five-membered ring aromatic heterocyclic molecules that consist of one carbon and four nitrogen atoms. Several tetrazole-based drugs have shown promising activities against bacteria, fungi, asthma, cancer, hypertension etc. The overall aim of this study was to determine anti-Acanthamoebic properties of tetrazoles and tetrazole-conjugated silver nanoparticles. Tetrazole-conjugated silver nanoparticles were synthesized and confirmed using ultraviolet–visible spectrometry, Dynamic light scattering, and Fourier-transform infrared spectroscopy. Using amoebicidal, encystment, and excystment assays, the findings revealed that tetrazoles exhibited antiamoebic properties and these effects were enhanced when conjugated with silver nanoparticles. Importantly, conjugation with silver nanoparticles inhibited parasite-mediated human cell death in vitro, as measured by lactate dehydrogenase release, but it reduced toxic effects of drugs alone on human cells. Overall, these results showed clearly that tetrazoles exhibit potent antiamoebic properties which can be enhanced by conjugation with silver nanoparticles and these potential in the rational development of therapeutic interventions against parasitic infections such as keratitis and granulomatous amoebic encephalitis due to pathogenic Acanthamoeba. © 2024 Elsevier Inc.
dc.description.sponsorshipAir Force Office of Scientific Research, NAK is supported by the Air Force Office of Scientific Research (AFOSR), USA.
dc.identifier.citationAnwar, A., Fatima, I., Khan, K. M., Daalah, M., Alawfi, B. S., Khan, N. A., & Anwar, A. (2024). Anti-Acanthamoebic effects of silver-conjugated tetrazole nanoparticle. Experimental Parasitology, 265, 108827.
dc.identifier.doi10.1016/j.exppara.2024.108827
dc.identifier.issn00144894
dc.identifier.pmid39147119
dc.identifier.scopus2-s2.0-85202967691
dc.identifier.scopusqualityQ3
dc.identifier.urihttp://dx.doi.org/10.1016/j.exppara.2024.108827
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6495
dc.identifier.volume265
dc.identifier.wosWOS:001309114300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKhan, Naveed Ahmed
dc.institutionauthoridNaveed Ahmed Khan / 0000-0001-7667-8553
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofExperimental Parasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDrugs
dc.subjectInfections
dc.subjectTreatment
dc.subjectParasites
dc.subjectManagement
dc.titleAnti-Acanthamoebic effects of silver-conjugated tetrazole nanoparticle
dc.typeArticle

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