Injectable and self-healing dual crosslinked gelatin/kappa-carrageenan methacryloyl hybrid hydrogels via host-guest supramolecular interaction for wound healing
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Injectable hydrogels based on natural polymers have shown great potential for various tissue engineering applications, such as wound healing. However, poor mechanical properties and weak self-healing ability are still major challenges. In this work, we introduce a host-guest (HG) supramolecular interaction between acrylate-beta-cyclodextrin (Ac-beta-CD) conjugated on methacrylated kappa-carrageenan (MA-kappa-CA) and aromatic residues on gelatin to provide self-healing characteristics. We synthesize an MA-kappa-CA to conjugate Ac-beta-CD and fabricate dual crosslinked hybrid hydrogels with gelatin to mimic the native extracellular matrix (ECM). The dual crosslinking occurs on the MA-kappa-CA backbone through the addition of KCl and photocrosslinking process, which enhances mechanical strength and stability. The hybrid hydrogels exhibit shear-thinning, self-healing, and injectable behavior, which apply easily under a minimally invasive manner and contribute to shear stress during the injection. Invitro studies indicate enhanced cell viability. Furthermore, scratch assays are performed to examine cell migration and cell-cell interaction. It is envisioned that the combination of self-healing and injectable dual crosslinked hybrid hydrogels with HG interactions display a promising and functional biomaterial platform for wound healing applications.
Açıklama
Anahtar Kelimeler
Dual Crosslinking, Gelatin, Kappa-Carrageenan, Host-Guest Interaction, Self-Healing Hydrogel, Wound Healing
Kaynak
Journal of Biomedical Materials Research Part B-Applied Biomaterials
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
111
Sayı
11
