Injectable and self-healing dual crosslinked gelatin/kappa-carrageenan methacryloyl hybrid hydrogels via host-guest supramolecular interaction for wound healing

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dc.authoridTorkay, Gülşah/0000-0002-6803-494X
dc.authoridYilmaz Aykut, Dilara/0000-0002-2287-2585
dc.authorwosidTorkay, Gülşah/IUP-3797-2023
dc.authorwosidYilmaz Aykut, Dilara/AAT-1255-2020
dc.contributor.authorYilmaz-Aykut, Dilara
dc.contributor.authorTorkay, Gulsah
dc.contributor.authorKasgoz, Alper
dc.contributor.authorShin, Su Ryon
dc.contributor.authorBal-Ozturk, Ayca
dc.contributor.authorDeligoz, Huseyin
dc.date.accessioned2024-05-19T14:40:58Z
dc.date.available2024-05-19T14:40:58Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractInjectable hydrogels based on natural polymers have shown great potential for various tissue engineering applications, such as wound healing. However, poor mechanical properties and weak self-healing ability are still major challenges. In this work, we introduce a host-guest (HG) supramolecular interaction between acrylate-beta-cyclodextrin (Ac-beta-CD) conjugated on methacrylated kappa-carrageenan (MA-kappa-CA) and aromatic residues on gelatin to provide self-healing characteristics. We synthesize an MA-kappa-CA to conjugate Ac-beta-CD and fabricate dual crosslinked hybrid hydrogels with gelatin to mimic the native extracellular matrix (ECM). The dual crosslinking occurs on the MA-kappa-CA backbone through the addition of KCl and photocrosslinking process, which enhances mechanical strength and stability. The hybrid hydrogels exhibit shear-thinning, self-healing, and injectable behavior, which apply easily under a minimally invasive manner and contribute to shear stress during the injection. Invitro studies indicate enhanced cell viability. Furthermore, scratch assays are performed to examine cell migration and cell-cell interaction. It is envisioned that the combination of self-healing and injectable dual crosslinked hybrid hydrogels with HG interactions display a promising and functional biomaterial platform for wound healing applications.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) 2214-A International Research Fellowship Programme [35056]; Council of Higher Education of Turkey 100/2000 National Ph.D. Scholarship Program; Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa; TUBITAK 2210/A MSc Scholarship Program; 2211/A Ph.D. Scholarship Program; [1059B142000022]; [1649B022101483]; [1649B031901750]en_US
dc.description.sponsorshipDilara Yilmaz-Aykut would like to acknowledge the financial support from the Scientific and Technological Research Council of Turkey (TUBITAK) 2214-A International Research Fellowship Programme for Ph.D. Student (App No: 1059B142000022), 2211/A Ph.D. Scholarship Program (App No: 1649B031901750), Council of Higher Education of Turkey 100/2000 National Ph.D. Scholarship Program, and Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa (Grant number 35056) provided the funding for this study. Guelsah Torkay would like to acknowledge the financial support from TUBITAK 2210/A MSc Scholarship Program (App No: 1649B022101483).en_US
dc.identifier.doi10.1002/jbm.b.35295
dc.identifier.endpage1937en_US
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue11en_US
dc.identifier.pmid37350561en_US
dc.identifier.scopus2-s2.0-85162861970en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1921en_US
dc.identifier.urihttps://doi.org10.1002/jbm.b.35295
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5043
dc.identifier.volume111en_US
dc.identifier.wosWOS:001019831800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biomedical Materials Research Part B-Applied Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDual Crosslinkingen_US
dc.subjectGelatinen_US
dc.subjectKappa-Carrageenanen_US
dc.subjectHost-Guest Interactionen_US
dc.subjectSelf-Healing Hydrogelen_US
dc.subjectWound Healingen_US
dc.titleInjectable and self-healing dual crosslinked gelatin/kappa-carrageenan methacryloyl hybrid hydrogels via host-guest supramolecular interaction for wound healingen_US
dc.typeArticleen_US

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