Application of microfluidic paper-based analytical device (mu PAD) to detect COVID-19 in energy deprived countries

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dc.authoridFarrukh Khalid / 0000-0003-4600-3496
dc.authorscopusidFarrukh Khalid / 55511857300
dc.authorwosidFarrukh Khalid / J-9609-2014
dc.contributor.authorChowdury, Mosfera A.
dc.contributor.authorKhalid, Farrukh
dc.date.accessioned2021-06-28T11:12:35Z
dc.date.available2021-06-28T11:12:35Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Makine Mühendisliği Bölümüen_US
dc.description.abstractCoronavirus disease (COVID-19) has spread all across the world. Low- and medium-income countries are more affected economically and socially compared to developed countries due to the lack of a rapid, robust, and affordable testing infrastructure. Furthermore, the high cost of real-time polymerase chain reaction (PCR) system, sophisticated user-handling procedure, and high expense of the conventional clinical tests are the root causes of the less accessibility of the testing systems to the users. In this study, a COVID-19 Point-of-Care (POC) ecosystem model is proposed for the low- and medium-income countries (or energy deprived countries) that will facilitate the technological development with locally available fabrication components. In addition, the nontechnological development phases have also been discussed, which encompasses the collaboration among academia, local as well as government bodies, and entrepreneurial ventures. In addition, a hypothetical design of a microfluidic paper-based analytical (mu PADs) POC platform is proposed to detect COVID-19 analyte using unprocessed patient-derived saliva, which is a miniaturized form-factor of conventional real-time polymerase chain reaction (PCR) technique. The device contains four major reaction zones, which are sample zone, buffer zone, loop-mediated isothermal amplification (LAMP) Master Mix zone, Ethylenediamine tetraacetic acid (EDTA) zone, and sensor zone. To obtain quicker test results and easier operation, a handheld image acquisition technique is introduced in this study. It is hypothesized that in a remote setting, the proposed design could be used as an initial guideline to develop a POC COVID-19 testing system, which may be simple, easy-to-use, and cost-effective.en_US
dc.identifier.citationChowdury, M. A., & Khalid, F. Application of microfluidic paper‐based analytical device (μPAD) to detect COVID‐19 in energy deprived countries. International Journal of Energy Research.en_US
dc.identifier.doi10.1002/er.6958en_US
dc.identifier.issn0363-907Xen_US
dc.identifier.issn1099-114Xen_US
dc.identifier.pmid34518727en_US
dc.identifier.scopus2-s2.0-85108184797en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/er.6958
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1854
dc.identifier.wosWOS:000662211400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKhalid, Farrukh
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ENERGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVIDen_US
dc.subjectMicrofluidicen_US
dc.subjectPoint-of-Careen_US
dc.titleApplication of microfluidic paper-based analytical device (mu PAD) to detect COVID-19 in energy deprived countriesen_US
dc.typeArticleen_US

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