Does the clamping method in local and systemic TXA applications in total knee arthroplasty change the game?: a retrospective comparative cohort study

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dc.authoridKaya Turan / 0000-0002-0547-995Xen_US
dc.authoridOsman Görkem Muratoğlu / 0000-0003-0049-7937
dc.authoridHaluk Çabuk / 0000-0002-1413-2149
dc.authoridRamazan Erden Ertürer / 0000-0003-4489-5937
dc.authoridTuğrul Ergün / 0000-0002-5615-3394
dc.authorscopusidKaya Turan / 57201721233en_US
dc.authorscopusidOsman Görkem Muratoğlu / 57214073565en_US
dc.authorscopusidHaluk Çabuk / 56400866300en_US
dc.authorscopusidRamazan Erden Ertürer / 57778248600en_US
dc.authorscopusidTuğrul Ergün / 57480960700en_US
dc.authorwosidOsman Görkem Muratoğlu / AGS-2887-2022
dc.authorwosidKaya Turan / AGA-7891-2022
dc.authorwosidHaluk Çabuk / AAL-9654-2020
dc.authorwosidRamazan Erden Ertürer / AAO-2634-2020
dc.authorwosidTuğrul Ergün / GPX-8467-2022
dc.contributor.authorTuran, Kaya
dc.contributor.authorMuratoğlu, Osman Görkem
dc.contributor.authorErgün, Tuğrul
dc.contributor.authorÇabuk, Haluk
dc.contributor.authorErtürer, Ramazan Erden
dc.date.accessioned2022-11-08T13:48:06Z
dc.date.available2022-11-08T13:48:06Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractMany different methods and drain clamping periods have been described in systemic and local tranexamic acid (TXA) applications, and the superiority of the methods to each other has not been clearly demonstrated. The method of local infusion in combined TXA applications may not alter the Hb drop or total or hidden blood loss. We aim to compare two different combined TXA application methods. We retrospectively analyzed 182 patients who underwent total knee arthroplasty between 2018 and 2021. Patients over 40 years of age who underwent TKA for degenerative knee arthritis were included in the study. Unicondylar, revision, or bilateral arthroplasties and patients with the cardiovascular or cerebrovascular disease were excluded from the study. All patients in the study received 1 g TXA intravenously half an hour before the incision. For the first group, 1 g TXA was given intra-articularly at the drain site after closure, and the clamp was kept closed for 1 hour. In the second group, the drain was clamped for an additional 6 hours, and a 1 g intravenous dose was administered at the 5th hour postoperatively. No local applications were used in the control group. Total, hidden, and visible blood loss (total blood loss, hidden blood loss, visible blood loss), postoperative decreases in hemoglobin and hematocrit level (?Hgb, ?Htc), blood transfusion rates, and hospital stay durations were evaluated. There were 72 patients in the first group, 52 in the second, and 58 in control. A total of 37 patients received one or more blood transfusions postoperatively, and there was no statistical difference in the need for blood transfusions between the groups (P?=?.255). Although a statistically significant difference (P?=?.001) in total blood loss, hidden blood loss, visible blood loss and ?Hgb values was observed between the groups, the difference between the first and second groups was insignificant (P?=?.512). The duration of hospital stay was observed to be less in the first and second groups (P?=?.024). Local and systemic TXA applications were observed to be more effective than only systemic applications in reducing blood loss after total knee arthroplasty, regardless of the local method.en_US
dc.identifier.citationTuran, K., Muratoǧlu, O. G., Ergün, T., Çabuk, H., & Ertürer, R. E. (2022). Does the clamping method in local and systemic TXA applications in total knee arthroplasty change the game?: A retrospective comparative cohort study. Medicine (United States), 101(38), E30823. doi:10.1097/MD.0000000000030823en_US
dc.identifier.doi10.1097/MD.0000000000030823en_US
dc.identifier.issue38en_US
dc.identifier.scopus2-s2.0-85139245872en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000030823
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3285
dc.identifier.volume101en_US
dc.identifier.wosWOS:000857180100032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuran, Kaya
dc.institutionauthorMuratoğlu, Osman Görkem
dc.institutionauthorÇabuk, Haluk
dc.institutionauthorErtürer, Ramazan Erden
dc.institutionauthorErgün, Tuğrul
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofMedicine (United States)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArthroplastyen_US
dc.subjectBlood Lossen_US
dc.subjectDrain Clampingen_US
dc.subjectKneeen_US
dc.subjectTranexamic Aciden_US
dc.titleDoes the clamping method in local and systemic TXA applications in total knee arthroplasty change the game?: a retrospective comparative cohort studyen_US
dc.typeArticleen_US

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