Effect of platelet count and platelet transfusion on fever duration in patients with febrile neutropenia
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Platelets play a role in hemostasis, thrombosis, and vascular integrity. They also play a major role in the development of inflammation and the activation of immune responses. They have phagocytic activity, stimulate the secretion of immune modulators, and activate other immune cells, which results in platelet-neutrophil aggregation, platelet-induced neutrophil degranulation, and the formation of neutrophil extracellular traps. Data on 124 febrile neutropenia attacks were retrospectively examined. Patients' age, sex, diagnosis, and relapse history were obtained. The complete blood count levels on the first and last febrile day of the febrile neutropenia attacks, duration of fever, and number, type, and timing of thrombocyte suspension transfusions were recorded. The patients were divided into three groups according to the day of fever when the platelet suspension was administered (1 day, 2-3 days, and >3 days); the duration of fever was compared between the three groups. The fever duration of those who were transfused with platelet suspension on the first day of fever was found to be significantly shorter (p = 0.03 and p < 0.001, respectively). When treating a patient with febrile neutropenia, if thrombocyte suspension transfusion is indicated, transfusing thrombocytes in the first days of fever shortens the fever duration and improves the prognosis of febrile neutropenia attack, supporting the hypothesis that not only neutrophils but also platelets may play a role in fighting against microorganisms.
Açıklama
Anahtar Kelimeler
Febrile Neutropenia, Immunothrombus, Netosis, Platelet-Neutrophil Relationship, Thrombocytopenia
Kaynak
Pediatric Hematology and Oncology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
1
Sayı
11
Künye
Öztosun B, Pirdal BZ, Çınar Özel S, Kaçar AG, Apak H, Celkan T. Effect of platelet count and platelet transfusion on fever duration in patients with febrile neutropenia. Pediatr Hematol Oncol. 2022 Jul 20:1-11. doi: 10.1080/08880018.2022.2066236. Epub ahead of print. PMID: 35855637.
