Effect of platelet count and platelet transfusion on fever duration in patients with febrile neutropenia

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dc.authoridTiraje Tülin Celkan / 0000-0001-7287-1276en_US
dc.authorscopusidTiraje Tülin Celkan / 35584411200
dc.authorwosidTiraje Tülin Celkan / AAI-1729-2019en_US
dc.contributor.authorÖztosun, Berrak
dc.contributor.authorPirdal, Betül Zehra
dc.contributor.authorÖzel Çınar, Simge
dc.contributor.authorGonca Kaçar, Ayşe
dc.contributor.authorApak, Hilmi
dc.contributor.authorCelkan, Tülin Tiraje
dc.date.accessioned2022-07-25T13:36:22Z
dc.date.available2022-07-25T13:36:22Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPlatelets play a role in hemostasis, thrombosis, and vascular integrity. They also play a major role in the development of inflammation and the activation of immune responses. They have phagocytic activity, stimulate the secretion of immune modulators, and activate other immune cells, which results in platelet-neutrophil aggregation, platelet-induced neutrophil degranulation, and the formation of neutrophil extracellular traps. Data on 124 febrile neutropenia attacks were retrospectively examined. Patients' age, sex, diagnosis, and relapse history were obtained. The complete blood count levels on the first and last febrile day of the febrile neutropenia attacks, duration of fever, and number, type, and timing of thrombocyte suspension transfusions were recorded. The patients were divided into three groups according to the day of fever when the platelet suspension was administered (1 day, 2-3 days, and >3 days); the duration of fever was compared between the three groups. The fever duration of those who were transfused with platelet suspension on the first day of fever was found to be significantly shorter (p = 0.03 and p < 0.001, respectively). When treating a patient with febrile neutropenia, if thrombocyte suspension transfusion is indicated, transfusing thrombocytes in the first days of fever shortens the fever duration and improves the prognosis of febrile neutropenia attack, supporting the hypothesis that not only neutrophils but also platelets may play a role in fighting against microorganisms.en_US
dc.identifier.citationÖztosun B, Pirdal BZ, Çınar Özel S, Kaçar AG, Apak H, Celkan T. Effect of platelet count and platelet transfusion on fever duration in patients with febrile neutropenia. Pediatr Hematol Oncol. 2022 Jul 20:1-11. doi: 10.1080/08880018.2022.2066236. Epub ahead of print. PMID: 35855637.en_US
dc.identifier.doi10.1080/08880018.2022.2066236en_US
dc.identifier.issn0888-0018en_US
dc.identifier.issue11en_US
dc.identifier.pmid35855637en_US
dc.identifier.scopus2-s2.0-85134596672en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttp://doi.org/10.1080/08880018.2022.2066236
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3039
dc.identifier.volume1en_US
dc.identifier.wosWOS:000828019500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCelkan, Tülin Tiraje
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofPediatric Hematology and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFebrile Neutropeniaen_US
dc.subjectImmunothrombusen_US
dc.subjectNetosisen_US
dc.subjectPlatelet-Neutrophil Relationshipen_US
dc.subjectThrombocytopeniaen_US
dc.titleEffect of platelet count and platelet transfusion on fever duration in patients with febrile neutropeniaen_US
dc.typeArticleen_US

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