Neuronal regeneration in injured rat spinal cord after human dental pulp derived neural crest stem cell transplantation

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023
dc.contributor.authorKabataş, S.
dc.contributor.authorDemir, C. S.
dc.contributor.authorCivelek, E.
dc.contributor.authorYılmaz, I.
dc.contributor.authorKırçelli, A.
dc.contributor.authorYılmaz, C.
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2020-08-30T20:07:54Z
dc.date.available2020-08-30T20:07:54Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: This study aimed to analyze the effect of human Dental Pulp-Neural Crest Stem Cells (hDP-NCSCs) delivery on lesion site after spinal cord injury (SCI), and to observe the functional recovery after transplantation. METHODS: Neural Crest Stem Cells (NCSCs) were isolated from human Dental Pulp (hDP). The experimental rat population was divided into four groups (n = 6/24). Their behavioral motility was scored regularly. After 4-weeks, rats were sacrificed, and their spinal cords were examined for Green Fluorescent Protein (GFP) labeled hDP-NCSCs by immunofluorescence (IF) staining. RESULTS: In early post-injury (p.i) period, the ultrastructure of spinal cord tissue was preserved in Group 4. The majority of cells forming the ependymal region around the central canal were found to be hDP-NCSCs. While the grey-and-white-matter around the ependymal region was composed of e.g. GFP cells, with astrocytic-like appearance. The scores showed significant motor recovery in hind limb functions in Group 4. However, no obvious change was observed in other groups. C ONCLUSION: Cells e.g., mesenchymal (Vimentin+) which express GFP+ cells in the gray-and-white-matter around the ependymal region could indicate the potential to self-renewal and plasticity. Thus, transplantation of hDP-NCSCs might be an effective strategy to improve functional recovery following spinal cord trauma (Fig. 10, Ref. 32). Text in PDF www.elis.sk.en_US
dc.identifier.citationKabatas, S., Demir, C. S., Civelek, E., Yilmaz, I., Kircelli, A., Yilmaz, C., … Karaoz, E. (2018). Neuronal regeneration in injured rat spinal cord after human dental pulp derived neural crest stem cell transplantation. Bratislava Medical Journal, 119(3), 143–151. https://doi.org/10.4149/BLL_2018_028en_US
dc.identifier.doi10.4149/BLL_2018_028en_US
dc.identifier.endpage151en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue3en_US
dc.identifier.pmid29536742en_US
dc.identifier.scopus2-s2.0-85044411914en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_028
dc.identifier.urihttps://hdl.handle.net/20.500.12713/850
dc.identifier.volume119en_US
dc.identifier.wosWOS:000428649600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaraöz, Erdalen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional Recoveryen_US
dc.subjectHuman Dental Pulpen_US
dc.subjectNeural Crest Stem Cellsen_US
dc.subjectSpinal Cord Injuryen_US
dc.titleNeuronal regeneration in injured rat spinal cord after human dental pulp derived neural crest stem cell transplantationen_US
dc.typeArticleen_US

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