Ex vivo regional mechanical characterization of porcine pulmonary arteries

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dc.authoridŞenol Pişkin / 0000-0002-8799-9472en_US
dc.authorscopusidŞenol Pişkin / 8636421200
dc.authorwosidŞenol Pişkin / JYJ-0063-2024
dc.contributor.authorPillalamarri, Narasimha Rao
dc.contributor.authorPatnaik, Sourav Sanchit
dc.contributor.authorPişkin, Şenol
dc.contributor.authorGueldner, P.
dc.contributor.authorFinol, Ender A.
dc.date.accessioned2021-01-15T12:31:45Z
dc.date.available2021-01-15T12:31:45Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Makine Mühendisliği Bölümüen_US
dc.description.abstractBackground: Regional mechanical characterization of pulmonary arteries can be useful in the development of computational models of pulmonary arterial mechanics. Objective: We performed a biomechanical and microstructural characterization study of porcine pulmonary arteries, inclusive of the main, left, and right pulmonary arteries (MPA, LPA, and RPA, respectively). Methods: The specimens were initially stored at ?20 °C and allowed to thaw for 12–24 h prior to testing. Each artery was further subdivided into proximal, middle, and distal regions, leading to ten location-based experimental groups. Planar equibiaxial tensile testing was performed to evaluate the mechanical behavior of the specimens, from which we calculated the stress at the maximum strain (S55), tensile modulus (TM), anisotropy index (AI), and strain energy in terms of area under the stress-strain curve (AUC). Histological quantification was performed to evaluate the area fraction of elastin and collagen content, intima-media thickness (IMT), and adventitial thickness (AT). The constitutive material behavior of each group was represented by a five-constant Holzapfel-Gasser-Ogden model. Results: The specimens exhibited non-linear stress-strain characteristics across all groups. The MPA exhibited the highest mean wall stress and TM in the longitudinal and circumferential directions, while the bifurcation region yielded the highest values of AI and AUC. All regions revealed a higher stiffness in the longitudinal direction compared to the circumferential direction, suggesting a degree of anisotropy that is believed to be within the margin of experimental uncertainty. Collagen content was found to be the highest in the MPA and decreased significantly at the bifurcation, LPA and RPA. Elastin content did not yield such significant differences amongst the ten groups. The MPA had the highest IMT, which decreased concomitantly to the distal LPA and RPA. No significant differences were found in the AT amongst the ten groups. Conclusion: The mechanical properties of porcine pulmonary arteries exhibit strong regional dissimilarities, which can be used to inform future studies of high fidelity finite element models.en_US
dc.identifier.citationPillalamarri, N. R., Patnaik, S. S., Piskin, S., Gueldner, P., & Finol, E. A. Ex Vivo Regional Mechanical Characterization of Porcine Pulmonary Arteries. Experimental Mechanics, 1-19.en_US
dc.identifier.doi10.1007/s11340-020-00678-2en_US
dc.identifier.issn0014-4851en_US
dc.identifier.pmid33814554en_US
dc.identifier.scopus2-s2.0-85099034348en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11340-020-00678-2
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1339
dc.identifier.wosWOS:000605568100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPişkin, Şenol
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofExperimental Mechanicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConstitutive Modelingen_US
dc.subjectHistologyen_US
dc.subjectPlanar Biaxial Tensionen_US
dc.subjectPulmonary Arterial Mechanicsen_US
dc.subjectPulmonary Hypertensionen_US
dc.titleEx vivo regional mechanical characterization of porcine pulmonary arteriesen_US
dc.typeArticleen_US

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