Succinate dehydrogenase complex iron sulfur subunit B (SDHB) immunohistochemistry in pheochromocytoma, head and neck paraganglioma, thoraco-abdomino-pelvic paragangliomas: is it a good idea to use in routine work?
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Asian Pacific Organization for Cancer Prevention
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods: A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p <0,01 is considered significant. Results: SDHB mutations are observed in 20 of 114 (17.54 %) PPGL cases, 3 (11,12%) of which is Pheo, 12 (16,44) is HNPGL, and 5 (35,71%) is TAPPGL (P <0,02). While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p <0,02), malignancy potential according to PASS classification (p <0,0001) and Ki-67 proliferation index (p <0,0001). Conclusion: To identify patients for molecular pathological examination, routine application of SDHB immunohistochemistry to PPGL tumors are suggested especially in HNPGLs.
Açıklama
Anahtar Kelimeler
Pheochromocytoma, SDHB, Immunohistochemistry, Paraganglioma
Kaynak
Asian Pac J Cancer Prev .
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
22
Sayı
6
Künye
Gul, A. E., Keser, S. H., Barisik, N. O., Gurbuz, Y. S., Sensu, S., & Erdogan, N. (2021). Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?. Asian Pacific journal of cancer prevention : APJCP, 22(6), 1721–1729. https://doi.org/10.31557/APJCP.2021.22.6.1721
