Succinate dehydrogenase complex iron sulfur subunit B (SDHB) immunohistochemistry in pheochromocytoma, head and neck paraganglioma, thoraco-abdomino-pelvic paragangliomas: is it a good idea to use in routine work?

Basit Öğe Kaydı
dc.authoridSibel Şensu / 0000-0002-4607-780Xen_US
dc.authoridNusret Erdoğan / 0000-0002-0333-8600en_US
dc.authoridYeşim Saliha Gürbüz / 0000-0002-4278-8241
dc.authorscopusidSibel Şensu / 35746731800
dc.authorscopusidYeşim Saliha Gürbüz / 7004052030
dc.authorscopusidNusret Erdoğan / 7004283152
dc.authorwosidSibel Şensu / AGU-9782-2022
dc.authorwosidYeşim Saliha Gürbüz / CRQ-9252-2022
dc.authorwosidNusret Erdoğan / K-6413-2018
dc.contributor.authorGül, Aylin Ege
dc.contributor.authorHallaç Keser, Sevinç
dc.contributor.authorÖzdemir Barışık, Nagehan
dc.contributor.authorGürbüz, Yeşim Saliha
dc.contributor.authorŞensu, Sibel
dc.contributor.authorErdoğan, Nusret
dc.date.accessioned2021-07-05T08:08:08Z
dc.date.available2021-07-05T08:08:08Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: In this study, we aimed to detect Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) frequency in paragangliomas and pheochromocytomas (PPGL) with immunohistochemistry; compare with Pheochromacytoma of the Adrenal Gland Scaled Score (PASS) classification and analyse the differences between pheochromocytoma (Pheo), head-neck paragangliomas (HNPGL) and thoraco-abdominal-pelvic paraganglioma (TAPPGL) sub-groups. Methods: A total 114 PPGL cases (73 HNPGL, 15 TAPPGL and 27 Pheo belonging to 112 cases) are included. Immunohistochemically, SDHB and Ki-67 are investigated and malignancy risks are determined by PASS classification. Results are assessed statistically with chi-square test and p <0,01 is considered significant. Results: SDHB mutations are observed in 20 of 114 (17.54 %) PPGL cases, 3 (11,12%) of which is Pheo, 12 (16,44) is HNPGL, and 5 (35,71%) is TAPPGL (P <0,02). While 15/82 (18,29%) cases with SDHB mutations do not have a malignancy potential according to PASS classification, 5/32 (15,63%) cases has (p=0,73). TAPPGL, HNPGL and Pheo sub-groups have a significant difference between SDHB expression (p <0,02), malignancy potential according to PASS classification (p <0,0001) and Ki-67 proliferation index (p <0,0001). Conclusion: To identify patients for molecular pathological examination, routine application of SDHB immunohistochemistry to PPGL tumors are suggested especially in HNPGLs.en_US
dc.identifier.citationGul, A. E., Keser, S. H., Barisik, N. O., Gurbuz, Y. S., Sensu, S., & Erdogan, N. (2021). Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB) Immunohistochemistry in Pheochromocytoma, Head and Neck Paraganglioma, Thoraco-Abdomino-Pelvic Paragangliomas: Is It a Good Idea to Use in Routine Work?. Asian Pacific journal of cancer prevention : APJCP, 22(6), 1721–1729. https://doi.org/10.31557/APJCP.2021.22.6.1721en_US
dc.identifier.doi10.31557/APJCP.2021.22.6.1721en_US
dc.identifier.endpage1729en_US
dc.identifier.issue6en_US
dc.identifier.pmid34181326en_US
dc.identifier.scopus2-s2.0-85109176712en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1721en_US
dc.identifier.urihttps://doi.org/10.31557/APJCP.2021.22.6.1721
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1870
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürbüz, Yeşim Saliha
dc.institutionauthorŞensu, Sibel
dc.institutionauthorErdoğan, Nusret
dc.language.isoenen_US
dc.publisherAsian Pacific Organization for Cancer Preventionen_US
dc.relation.ispartofAsian Pac J Cancer Prev .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPheochromocytomaen_US
dc.subjectSDHBen_US
dc.subjectImmunohistochemistryen_US
dc.subjectParagangliomaen_US
dc.titleSuccinate dehydrogenase complex iron sulfur subunit B (SDHB) immunohistochemistry in pheochromocytoma, head and neck paraganglioma, thoraco-abdomino-pelvic paragangliomas: is it a good idea to use in routine work?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
64.pdf
Boyut:
1.68 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu