Selective targeting of signet ring cell adenocarcinomas

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dc.authoridAbdullah Olgun / 0000-0002-6976-9286en_US
dc.authorscopusidAbdullah Olgun / 6603877209
dc.authorwosidAbdullah Olgun / FPP-8980-2022
dc.contributor.authorOlgun, Abdullah
dc.date.accessioned2020-08-30T20:06:25Z
dc.date.available2020-08-30T20:06:25Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractMany epithelial tumors, especially signet-ring cell adenocarcinomas, produce huge amounts of mucin glycoproteins that fill cytoplasm and push nucleus to the periphery, giving a signet ring like structure to the cell. Mucin proteins are very rich of l-threonine which is essential in humans. L-threonine content can reach up to 35% of total amino acid composition of some mucin proteins. Therefore l-threonine can be the Achilles heel of signet ring cell adenocarcinomas which are one of the most malignant and agressive cancers. A modified bioisoster of l-threonine, 4-fluoro l-threonine (its fluorine can be radioactive or not), can be used to selectively kill signet ring cancer cells without harming normal cells or for diagnostic purposes.en_US
dc.identifier.citationOlgun, A. (2019). Selective targeting of signet ring cell adenocarcinomas. MEDICAL HYPOTHESES, 133. https://doi.org/10.1016/j.mehy.2019.109380en_US
dc.identifier.doi10.1016/j.mehy.2019.109380en_US
dc.identifier.issn0306-9877en_US
dc.identifier.issn1532-2777en_US
dc.identifier.pmid31454636en_US
dc.identifier.scopus2-s2.0-85071099394en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2019.109380
dc.identifier.urihttps://hdl.handle.net/20.500.12713/512
dc.identifier.volume133en_US
dc.identifier.wosWOS:000500360500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOlgun, Abdullahen_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSignet-Ring Cell Canceren_US
dc.subjectMucin Proteinsen_US
dc.subject4-Fluoro L-Threonineen_US
dc.subjectSystemic Radiotherapyen_US
dc.titleSelective targeting of signet ring cell adenocarcinomasen_US
dc.typeArticleen_US
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