Long-term results of splenectomy in transfusion-dependent thalassemia
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walters Kluwer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Splenectomy is indicated in transfusion-dependent thalassemia (TDT) only in certain situations. This study aimed to present the effectiveness, complications, and long-term follow-up results of splenectomy in children with TDT. We performed a 30-year single-institution analysis of cases of splenectomy for TDT between 1987 and 2017 and their follow-up until 2021. A total of 39 children (female/male: 24/15) were included. The mean age at splenectomy was 11.2 ± 3.2 years, and their mean follow-up duration after splenectomy was 21.5 ± 6.4 years. Response was defined according to the patient’s annual transfusion requirement in the first year postsplenectomy and on the last follow-up year. Complete response was not seen in any of the cases; partial response was observed in 32.3% and no response in 67.6%. Thrombocytosis was seen in 87% of the patients. The platelet counts of 7 (17.9%) patients were > 1000 (109 /L), and aspirin prophylaxis was given to 22 (56.4%) patients. Complications were thrombosis in 2 (5.1%) patients, infections in 11 (28.2%) patients, and pulmonary hypertension in 4 (10.2%) patients. Our study showed that after splenectomy, the need for transfusion only partially decreased in a small number of TDT patients. We think splenectomy can be delayed with appropriate chelation therapy up to higher annual transfusion requirement values
Açıklama
Anahtar Kelimeler
Splenectomy, Children, Thalassemia, Transfusiondependent, Long-term
Kaynak
Journal of Pediatric Hematology Oncology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Akca T, Ozdemir GN, Aycicek A, Ozkaya G. Long-term Results of Splenectomy in Transfusion-dependent Thalassemia. J Pediatr Hematol Oncol. 2022 Apr 19. doi: 10.1097/MPH.0000000000002468. Epub ahead of print. PMID: 35446800.
