Long-term results of splenectomy in transfusion-dependent thalassemia

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dc.authoridGül Nihal Özdemir / 0000-0002-3204-4353en_US
dc.authorscopusidGül Nihal Özdemir / 34067792800
dc.authorwosidGül Nihal Özdemir / AAO-9962-2020en_US
dc.contributor.authorAkça, Tuğberk
dc.contributor.authorAyçiçek, Ali
dc.contributor.authorÖzkaya, Güven
dc.contributor.authorÖzdemir, Gül Nihal
dc.date.accessioned2022-05-23T08:39:31Z
dc.date.available2022-05-23T08:39:31Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSplenectomy is indicated in transfusion-dependent thalassemia (TDT) only in certain situations. This study aimed to present the effectiveness, complications, and long-term follow-up results of splenectomy in children with TDT. We performed a 30-year single-institution analysis of cases of splenectomy for TDT between 1987 and 2017 and their follow-up until 2021. A total of 39 children (female/male: 24/15) were included. The mean age at splenectomy was 11.2 ± 3.2 years, and their mean follow-up duration after splenectomy was 21.5 ± 6.4 years. Response was defined according to the patient’s annual transfusion requirement in the first year postsplenectomy and on the last follow-up year. Complete response was not seen in any of the cases; partial response was observed in 32.3% and no response in 67.6%. Thrombocytosis was seen in 87% of the patients. The platelet counts of 7 (17.9%) patients were > 1000 (109 /L), and aspirin prophylaxis was given to 22 (56.4%) patients. Complications were thrombosis in 2 (5.1%) patients, infections in 11 (28.2%) patients, and pulmonary hypertension in 4 (10.2%) patients. Our study showed that after splenectomy, the need for transfusion only partially decreased in a small number of TDT patients. We think splenectomy can be delayed with appropriate chelation therapy up to higher annual transfusion requirement valuesen_US
dc.identifier.citationAkca T, Ozdemir GN, Aycicek A, Ozkaya G. Long-term Results of Splenectomy in Transfusion-dependent Thalassemia. J Pediatr Hematol Oncol. 2022 Apr 19. doi: 10.1097/MPH.0000000000002468. Epub ahead of print. PMID: 35446800.en_US
dc.identifier.doi10.1097/MPH.0000000000002468en_US
dc.identifier.issn1077-4114en_US
dc.identifier.pmid35446800en_US
dc.identifier.scopus2-s2.0-85129547642en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttp://doi.org/10.1097/MPH.0000000000002468
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2713
dc.identifier.wosWOS:000957943100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzdemir, Gül Nihal
dc.language.isoenen_US
dc.publisherWalters Kluweren_US
dc.relation.ispartofJournal of Pediatric Hematology Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSplenectomyen_US
dc.subjectChildrenen_US
dc.subjectThalassemiaen_US
dc.subjectTransfusiondependenten_US
dc.subjectLong-termen_US
dc.titleLong-term results of splenectomy in transfusion-dependent thalassemiaen_US
dc.typeArticleen_US

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