A comprehensive review on novel targeted therapy methods and nanotechnology-based gene delivery systems in melanoma

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dc.authoridCordani, Marco/0000-0001-9342-4862
dc.authoridRahimmanesh, Ilnaz/0000-0003-3438-1959
dc.authoridEsmaeili, Yasaman/0000-0002-3661-0260
dc.authorwosidShaghayeg Javanmard, Haghjoo/V-6376-2017
dc.authorwosidCordani, Marco/ABF-4669-2021
dc.authorwosidRahimmanesh, Ilnaz/CAA-2321-2022
dc.contributor.authorRahimi, Azadeh
dc.contributor.authorEsmaeili, Yasaman
dc.contributor.authorDana, Nasim
dc.contributor.authorDabiri, Arezou
dc.contributor.authorRahimmanesh, Ilnaz
dc.contributor.authorJandaghian, Setareh
dc.contributor.authorVaseghi, Golnaz
dc.date.accessioned2024-05-19T14:45:47Z
dc.date.available2024-05-19T14:45:47Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMelanoma, a malignant form of skin cancer, has been swiftly increasing in recent years. Although there have been significant advancements in clinical treatment underlying a well-understanding of melanoma-susceptible genes and the molecular basis of melanoma pathogenesis, the permanency of response to therapy is frequently constrained by the emergence of acquired resistance and systemic toxicity. Conventional therapies, including surgical resection, chemotherapy, radiotherapy, and immunotherapy, have already been used to treat melanoma and are dependent on the cancer stage. Nevertheless, ineffective side effects and the heterogeneity of tumors pose major obstacles to the therapeutic treatment of malignant melanoma through such strategies. In light of this, advanced therapies including nucleic acid therapies (ncRNA, aptamers), suicide gene therapies, and gene therapy using tumor suppressor genes, have lately gained immense attention in the field of cancer treat-ment. Furthermore, nanomedicine and targeted therapy based on gene editing tools have been applied to the treatment of melanoma as potential cancer treatment approaches nowadays. Indeed, nanovectors enable delivery of the therapeutic agents into the tumor sites by passive or active targeting, improving therapeutic efficiency and minimizing adverse effects. Accordingly, in this review, we summarized the recent findings related to novel targeted therapy methods as well as nanotechnology-based gene systems in melanoma. We also discussed current issues along with potential directions for future research, paving the way for the next-generation of melanoma treatments.en_US
dc.description.sponsorshipIsfahan University of Medical Sciences [198142]; Spanish Ministry of Science and Innovation, Agencia Estatal de Investigacion (MCIN/AEI); European UnionNextGeneration (EU/PRTR); Spanish Ministry of Universities; European Union NextGeneration; Complutense University of Madrid; [RYC2021-031003-I]en_US
dc.description.sponsorshipS.H.J. is deeply grateful to Isfahan University of Medical Sciences, Deputy of Research for their research support (Grant No. 198142) . M.C. was supported with a Ramon y Cajal contract from the Spanish Ministry of Science and Innovation, Agencia Estatal de Investigacion (MCIN/AEI/10.13039/501100011033) , and European UnionNextGeneration (EU/PRTR) , funding reference: RYC2021-031003-I. M.C. was also funded by Maria Zambrano contract from Spanish Ministry of Universities, European Union NextGeneration and Complutense University of Madrid.en_US
dc.identifier.doi10.1016/j.ejps.2023.106476
dc.identifier.issn0928-0987
dc.identifier.issn1879-0720
dc.identifier.pmid37236377en_US
dc.identifier.scopus2-s2.0-85161039467en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.ejps.2023.106476
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5346
dc.identifier.volume187en_US
dc.identifier.wosWOS:001012722200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMelanomaen_US
dc.subjectNanomedicineen_US
dc.subjectGene Deliveryen_US
dc.subjectTargeted Therapyen_US
dc.subjectNanovectorsen_US
dc.titleA comprehensive review on novel targeted therapy methods and nanotechnology-based gene delivery systems in melanomaen_US
dc.typeArticleen_US

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