Effect of tranexamic acid on fracture Heling in Rats [Efeito do acido tranexamico na cura de fratura em ratos]
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sociedade Brasileira de Ortopedia e Traumatologia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: In this study we investigated the effect of tranexamic acid (TXA) on fracture healing in an established animal model, when used to stop bleeding in orthopedic trauma surgery. Materials and Methods: This study was a randomized, controlled, laboratory study. Eighteen Sprague-Dawley rats were randomly assigned to three groups, either receiving TXA intravenously (Group 1), TXA topically (Group 2), or isotonic TXA intravenously and TXA topically in the same amounts for the control group (Group 3). First, a Kirschner wire was inserted retrogradely into the femoral intramedullary canal. Then the femurs were fractured at the midshaft region with blunt guillotine. After 4 weeks, the rats were sacrified and the femurs harvested. Cortical bone volume, callus volume, and bone mineral density were calculated using computer tomography scans. Torsion tests were performed. Groups were compared by maximum torque to failure and callus stiffness. Results: There were no statistical differences in torque to failure and stiffness between the 3 groups. There were no differences in mean total bone volume, callus volume, percent bone volume, or callus density between the groups. Conclusions: A single dose of topical or intravenous TXA has no negative effect on fracture healing when used in traumatic femur fracture surgery in an animal model. Evidence level II; Randomized controlled experimental study. © 2022. All Rights Reserved.
Açıklama
Anahtar Kelimeler
Cirurgia Ortopédica, Fracture, Fratura, Orthopedic Surgery, Tranexamic Acid, Ácido Tranexâmico
Kaynak
Acta Ortopedica Brasileira
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
30
Sayı
1
Künye
Bayram, E., Yunlu, M., Gulabi, D., Bozdag, E., Yİlmaz, M., & Atlihan, D. (2022). EFFECT OF TRANEXAMIC ACID ON FRACTURE HEALING IN RATS. [EFEITO DO ÁCIDO TRANEXÂMICO NA CURA DE FRATURA EM RATOS] Acta Ortopedica Brasileira, 30(1), 1-4. doi:10.1590/1413-785220223001e245670
