Effect of tranexamic acid on fracture Heling in Rats [Efeito do acido tranexamico na cura de fratura em ratos]

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dc.authoridErhan Bayram / 0000-0002-9426-2831
dc.authorscopusidErhan Bayram / 56704760000
dc.authorwosidErhan Bayram / HJH-5360-2023
dc.contributor.authorBayram, Erhan
dc.contributor.authorYünlü, Mehmet
dc.contributor.authorGülabi, Deniz
dc.contributor.authorBozdağ, Ergün
dc.contributor.authorYılmaz, Murat
dc.contributor.authorAtlıhan, Doğan
dc.date.accessioned2022-03-23T05:50:33Z
dc.date.available2022-03-23T05:50:33Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractIntroduction: In this study we investigated the effect of tranexamic acid (TXA) on fracture healing in an established animal model, when used to stop bleeding in orthopedic trauma surgery. Materials and Methods: This study was a randomized, controlled, laboratory study. Eighteen Sprague-Dawley rats were randomly assigned to three groups, either receiving TXA intravenously (Group 1), TXA topically (Group 2), or isotonic TXA intravenously and TXA topically in the same amounts for the control group (Group 3). First, a Kirschner wire was inserted retrogradely into the femoral intramedullary canal. Then the femurs were fractured at the midshaft region with blunt guillotine. After 4 weeks, the rats were sacrified and the femurs harvested. Cortical bone volume, callus volume, and bone mineral density were calculated using computer tomography scans. Torsion tests were performed. Groups were compared by maximum torque to failure and callus stiffness. Results: There were no statistical differences in torque to failure and stiffness between the 3 groups. There were no differences in mean total bone volume, callus volume, percent bone volume, or callus density between the groups. Conclusions: A single dose of topical or intravenous TXA has no negative effect on fracture healing when used in traumatic femur fracture surgery in an animal model. Evidence level II; Randomized controlled experimental study. © 2022. All Rights Reserved.en_US
dc.identifier.citationBayram, E., Yunlu, M., Gulabi, D., Bozdag, E., Yİlmaz, M., & Atlihan, D. (2022). EFFECT OF TRANEXAMIC ACID ON FRACTURE HEALING IN RATS. [EFEITO DO ÁCIDO TRANEXÂMICO NA CURA DE FRATURA EM RATOS] Acta Ortopedica Brasileira, 30(1), 1-4. doi:10.1590/1413-785220223001e245670en_US
dc.identifier.doi10.1590/1413-785220223001e245670en_US
dc.identifier.endpage4en_US
dc.identifier.issn1413-7852en_US
dc.identifier.issue1en_US
dc.identifier.pmid35431630en_US
dc.identifier.scopus2-s2.0-85126363531en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1590/1413-785220223001e245670
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2562
dc.identifier.volume30en_US
dc.identifier.wosWOS:000752525100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBayram, Erhan
dc.language.isoenen_US
dc.publisherSociedade Brasileira de Ortopedia e Traumatologiaen_US
dc.relation.ispartofActa Ortopedica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCirurgia Ortopédicaen_US
dc.subjectFractureen_US
dc.subjectFraturaen_US
dc.subjectOrthopedic Surgeryen_US
dc.subjectTranexamic Aciden_US
dc.subjectÁcido Tranexâmicoen_US
dc.titleEffect of tranexamic acid on fracture Heling in Rats [Efeito do acido tranexamico na cura de fratura em ratos]en_US
dc.typeArticleen_US

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