Does ß-glucan can have a protective role against oxidative stress in the experimental sepsis model in rats?

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dc.authoridMeltem Demir / 0000-0002-0836-8585en_US
dc.authorscopusidMeltem Demir / 56689396100
dc.authorwosidMeltem Demir / ERD-5630-2022
dc.contributor.authorDemir, Meltem
dc.contributor.authorKöse, Kader
dc.contributor.authorYazıcı, Cevat
dc.contributor.authorSözüer, Erdoğan Mütevelli
dc.date.accessioned2020-09-24T13:46:29Z
dc.date.available2020-09-24T13:46:29Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: Very high mortality rate in sepsis may be related to oxidative stress. This study was conducted on the rats to investigate the presence of oxidative stress and also the potential protective effects of the ß-glucan in the intra-abdominal sepsis model formed by cecal ligation-perforation (CLP). METHODS: In this study, 30 Male rats were equally divided into three groups as “Sham”, “Sepsis” and “ß-Glucan”. Only laparotomy was performed in the Sham group, and sepsis was induced by CLP in Sepsis and ß-Glucan groups. Following CLP, a single dose of 4 mg ß-glucan/kg was also intraperitoneally administered to the ?-Glucan group. Blood and tissue (liver, lung and kidney) samples were taken from Sepsis and ß-Glucan groups after sepsis development determined at the end of the 48th hour, also from the Sham group. The levels of myeloperoxidase (MPO) and advanced oxidation protein products (AOPP) were determined in plasma samples, and the malondialdehyde (MDA) was measured in plasma and tissues. RESULTS: MPO and AOPP were higher in both the Sepsis and ß-Glucan groups; however, plasma and tissue MDA levels were higher only in the Sepsis group than the Sham group (p<0.05). However, when compared to the Sepsis group, all parameters measured, except kidney MDA, were significantly lower in the ß-Glucan group (p<0.05). CONCLUSION: To our knowledge, this is the first study to investigate the AOPP levels in the CLP sepsis model, ROS produced by the reaction of MPO derived from neutrophils may form oxidative damage to the proteins, compared to the lipids, and ß-glucan may be used as an alternative agent for sepsis treatment. © 2020 Turkish Association of Trauma and Emergency Surgery.en_US
dc.identifier.citationDemir, M., Köse, K., Yazıcı, C., & Sözüer, E. M. (2020). Does ß-glucan can have a protective role against oxidative stress in the experimental sepsis model in rats? [ß-glukan, sıçanlarda deneysel sepsis modelinde oksidatif strese karşı koruyucu rol oynayabilir mi?] Ulusal Travma Ve Acil Cerrahi Dergisi, 26(5), 657-662. doi:10.14744/tjtes.2019.79002en_US
dc.identifier.doi10.14744/tjtes.2019.79002en_US
dc.identifier.endpage662en_US
dc.identifier.issn1306696Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid32946102en_US
dc.identifier.scopus2-s2.0-85091048341en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage657en_US
dc.identifier.trdizinid372471en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2019.79002
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1084
dc.identifier.volume26en_US
dc.identifier.wosWOS:000580594400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemir, Meltem
dc.language.isoenen_US
dc.publisherTurkish Association of Trauma and Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdvanced Oxidation Protein Productsen_US
dc.subjectB-Glucanen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectSepsisen_US
dc.titleDoes ß-glucan can have a protective role against oxidative stress in the experimental sepsis model in rats?en_US
dc.title.alternativeß-glukan, sıçanlarda deneysel sepsis modelinde oksidatif strese karşı koruyucu rol oynayabilir mi?en_US
dc.typeArticleen_US

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