The repertoire of glycan alterations and glycoproteins in human cancers

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dc.authoridAyşegül Çalışkan İşcan / 0000-0003-1887-9167
dc.authorscopusidAyşegül Çalışkan İşcan / 57217079641
dc.authorwosidAyşegül Çalışkan İşcan / GNJ-6483-2022
dc.contributor.authorKori, Medi
dc.contributor.authorAydın, Büşra
dc.contributor.authorGülfidan, Gizem
dc.contributor.authorBeklen, Hande
dc.contributor.authorKelesoglu, Nurdan
dc.contributor.authorÇalışkan İşcan, Ayşegül
dc.contributor.authorTuranli, Beste
dc.contributor.authorErzik, Can
dc.contributor.authorKarademir, Betul
dc.contributor.authorArga, Kazim Yalcin
dc.date.accessioned2021-01-11T07:34:06Z
dc.date.available2021-01-11T07:34:06Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractCancer as the leading cause of death worldwide has many issues that still need to be addressed. Since the alterations on the glycan compositions or/and structures (i.e., glycosylation, sialylation, and fucosylation) are common features of tumorigenesis, glycomics becomes an emerging field examining the structure and function of glycans. In the past, cancer studies heavily relied on genomics and transcriptomics with relatively little exploration of the glycan alterations and glycoprotein biomarkers among individuals and populations. Since glycosylation of proteins increases their structural complexity by several orders of magnitude, glycome studies resulted in highly dynamic biomarkers that can be evaluated for cancer diagnosis, prognosis, and therapy. Glycome not only integrates our genetic background with past and present environmental factors but also offers a promise of more efficient patient stratification compared with genetic variations. Therefore, studying glycans holds great potential for better diagnostic markers as well as developing more efficient treatment strategies in human cancers. While recent developments in glycomics and associated technologies now offer new possibilities to achieve a high-throughput profiling of glycan diversity, we aim to give an overview of the current status of glycan research and the potential applications of the glycans in the scope of the personalized medicine strategies for cancer.en_US
dc.identifier.citationKori, M., Aydin, B., Gulfidan, G., Beklen, H., Kelesoglu, N., Caliskan Iscan, A., Turanli, B., Erzik, C., Karademir, B., & Arga, K. Y. (2021). The Repertoire of Glycan Alterations and Glycoproteins in Human Cancers. Omics : a journal of integrative biology, 10.1089/omi.2020.0210. Advance online publication. https://doi.org/10.1089/omi.2020.0210en_US
dc.identifier.doi10.1089/omi.2020.0210en_US
dc.identifier.issn1536-2310en_US
dc.identifier.issn1557-8100en_US
dc.identifier.pmid33404348en_US
dc.identifier.scopus2-s2.0-85101199640en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1089/omi.2020.0210
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1308
dc.identifier.wosWOS:000628899900003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇalışkan İşcan, Ayşegül
dc.language.isoenen_US
dc.relation.ispartofOMICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectFucosylation and Personalized Medicineen_US
dc.subjectGlycanen_US
dc.subjectGlycan Alterationen_US
dc.subjectGlycoproteinen_US
dc.subjectGlycosylationen_US
dc.subjectSialylationen_US
dc.subjectTumoren_US
dc.titleThe repertoire of glycan alterations and glycoproteins in human cancersen_US
dc.typeArticleen_US

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