Pre-treatment and post-treatment neutrophil-to-lymphocyte ratio predict pathological tumor response and survival in rectal cancer patients treated with neoadjuvant chemoradiotherapy

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Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

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KARE PUBL

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

OBJECTIVE The aim of this study is to investigate the relationship between baseline and post-treatment neutrophil-to-lymphocyte ratio (NLR) levels and response to neoadjuvant chemoradiotherapy (CRT) in terms of good pathological response and survival. METHODS Fifty-six patients who underwent neoadjuvant CRT and curative surgery for locally advanced rectal cancer (LARC) were analyzed retrospectively. Pre-CRT and post-CRT hematologic parameters were recorded. The link between NLR and clinical outcomes was explored. RESULTS The receiver operating characteristic analysis revealed appropriate cut-off values of 2.87 for pre-CRT NLR associated with good pathological response and 8.68 for post-CRT NLR predicting survival. The low pre-CRT NLR group had better outcomes in terms of good pathological response compared to the high pre-CRT NLA group (OR 4.15, 95% CI 1.23-13.76, p=0.021). However, the analysis failed to show the correlation between NLR and pCR (OR 2.74, 95% CI 0.37-20.15, p=0.320). Patients with elevated post-CRT NLR had significantly worse 5-year overall survival (OS), disease-free survival (DFS) and local regional recurrence-free survival (LRRFS) rates compared to low post-CRT NLR in multivariate analysis (46.6% vs. 74.4%, p=0.020; 35.3% vs. 71.9%, p=0.018; 40.8% vs. 78.1%, p=0.006). CONCLUSION High pre-CRT NLR might be used as a poor pathological tumor response predictor in LARC patients treated with neoadjuvant CRT. In addition, low post-CRT NLR is associated with favorable OS, DFS, and LRRFS. Therefore, easily accessible and cost-effective NLR can be considered as a potential predictive marker to identify patients and establish personalized treatment strategies.

Açıklama

Anahtar Kelimeler

Neoadjuvant Chemoradiotherapy, Neutrophil-to-lymphocyte Ratio, Pathological Tumor Response, Prognosisrectal Cancersurvival

Kaynak

TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY

WoS Q Değeri

N/A

Scopus Q Değeri

Q4

Cilt

Sayı

Künye

Delikgoz Soykut, E., Kemal, Y., Odabasi, E., Odabasi, E., Sahin, N., Keskinkilic Yagiz, B., Yazicioglu, I. M., Aytac Arslan, S., Guney, V. (2022). Pre-treatment and post-treatment neutrophil-to-lymphocyte ratio predict pathological tumor response and survival in rectal cancer patients treated with neoadjuvant chemoradiotherapy. Turk Onkoloji Dergisi-Turkish Journal of Oncology.