Pre-treatment and post-treatment neutrophil-to-lymphocyte ratio predict pathological tumor response and survival in rectal cancer patients treated with neoadjuvant chemoradiotherapy

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dc.authoridYasemin Kemal / 0000-0002-1175-9085
dc.authorscopusidYasemin Kemal / 23479972900
dc.authorwosidYasemin Kemal / CYJ-7779-2022
dc.contributor.authorDelikgöz Soykut, Ela
dc.contributor.authorKemal, Yasemin
dc.contributor.authorOdabaşı, Eylem
dc.contributor.authorŞahin, Nilgün
dc.contributor.authorKeskinkılıç Yağız, Betül
dc.date.accessioned2022-04-11T11:33:40Z
dc.date.available2022-04-11T11:33:40Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractOBJECTIVE The aim of this study is to investigate the relationship between baseline and post-treatment neutrophil-to-lymphocyte ratio (NLR) levels and response to neoadjuvant chemoradiotherapy (CRT) in terms of good pathological response and survival. METHODS Fifty-six patients who underwent neoadjuvant CRT and curative surgery for locally advanced rectal cancer (LARC) were analyzed retrospectively. Pre-CRT and post-CRT hematologic parameters were recorded. The link between NLR and clinical outcomes was explored. RESULTS The receiver operating characteristic analysis revealed appropriate cut-off values of 2.87 for pre-CRT NLR associated with good pathological response and 8.68 for post-CRT NLR predicting survival. The low pre-CRT NLR group had better outcomes in terms of good pathological response compared to the high pre-CRT NLA group (OR 4.15, 95% CI 1.23-13.76, p=0.021). However, the analysis failed to show the correlation between NLR and pCR (OR 2.74, 95% CI 0.37-20.15, p=0.320). Patients with elevated post-CRT NLR had significantly worse 5-year overall survival (OS), disease-free survival (DFS) and local regional recurrence-free survival (LRRFS) rates compared to low post-CRT NLR in multivariate analysis (46.6% vs. 74.4%, p=0.020; 35.3% vs. 71.9%, p=0.018; 40.8% vs. 78.1%, p=0.006). CONCLUSION High pre-CRT NLR might be used as a poor pathological tumor response predictor in LARC patients treated with neoadjuvant CRT. In addition, low post-CRT NLR is associated with favorable OS, DFS, and LRRFS. Therefore, easily accessible and cost-effective NLR can be considered as a potential predictive marker to identify patients and establish personalized treatment strategies.en_US
dc.identifier.citationDelikgoz Soykut, E., Kemal, Y., Odabasi, E., Odabasi, E., Sahin, N., Keskinkilic Yagiz, B., Yazicioglu, I. M., Aytac Arslan, S., Guney, V. (2022). Pre-treatment and post-treatment neutrophil-to-lymphocyte ratio predict pathological tumor response and survival in rectal cancer patients treated with neoadjuvant chemoradiotherapy. Turk Onkoloji Dergisi-Turkish Journal of Oncology.en_US
dc.identifier.doi10.5505/tjo.2022.3467en_US
dc.identifier.issn1300-7467en_US
dc.identifier.scopus2-s2.0-85132762050en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.trdizinid1136703en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2022.3467
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2624
dc.identifier.wosWOS:000767314500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKemal, Yasemin
dc.language.isoenen_US
dc.publisherKARE PUBLen_US
dc.relation.ispartofTURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeoadjuvant Chemoradiotherapyen_US
dc.subjectNeutrophil-to-lymphocyte Ratioen_US
dc.subjectPathological Tumor Responseen_US
dc.subjectPrognosisrectal Cancersurvivalen_US
dc.titlePre-treatment and post-treatment neutrophil-to-lymphocyte ratio predict pathological tumor response and survival in rectal cancer patients treated with neoadjuvant chemoradiotherapyen_US
dc.typeArticleen_US

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