Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authorscopusidAyça Bal Öztürk / 57062000100en_US
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorOğuz, Nesrin
dc.contributor.authorTekarslan Şahin, Hande
dc.contributor.authorEmik, Serkan
dc.contributor.authorAlarcin, Emine
dc.date.accessioned2022-06-17T09:01:04Z
dc.date.available2022-06-17T09:01:04Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.description.abstractAn amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-bpoly(?-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, 1 H NMR, 13 C NMR, and GPC analysis. Monodisperse HPAE-PCL-b-MPEG nanoparticles with dimensions of <200 nm and polydispersity index of <0.5 were prepared by nanoprecipitation method and characterized with SEM, particle size, and zeta potential analysis. 5-Fluorouracil was encapsulated within HPAE-PCL-b-MPEG nanoparticles. In vitro drug release profiles and cytotoxicity of blank and 5-fluorouracil-loaded nanoparticles were examined against the human colon cancer HCT116 cell line. All results suggest that HPAE-PCL-b-MPEG nanoparticles offer an alternative and effective drug nanocarrier system for drug delivery applications. © TÜBİTAK.en_US
dc.identifier.citationBal Öztürk, A., Oğuz, N., Tekarslan Şahin, H., Emik, S., & Alarçin, E. (2020). Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery. Turkish Journal of Chemistry, 44(2), 518-534. doi:10.3906/KIM-1910-35en_US
dc.identifier.doi10.3906/KIM-1910-35en_US
dc.identifier.endpage534en_US
dc.identifier.issn1300-0527en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85085992847en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage518en_US
dc.identifier.trdizinid335274en_US
dc.identifier.urihttps://doi.org/10.3906/KIM-1910-35
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2919
dc.identifier.volume44en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherTUBITAKen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5−Fluorouracilen_US
dc.subjectDrug Deliveryen_US
dc.subjectHyperbranched Polymeren_US
dc.subjectNanoparticleen_US
dc.subjectPoly(Aminoester)en_US
dc.titleDesign of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug deliveryen_US
dc.typeArticleen_US

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