Effect of renal function on the prognostic importance of chloride in patients with heart failure

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dc.authoridYILMAZ, Mehmet Birhan/0000-0002-8169-8628
dc.authoridGüvenç, Tolga Sinan/0000-0002-6738-266X
dc.authoridÇELİK, AHMET/0000-0002-9417-7610
dc.authorwosidYILMAZ, Mehmet Birhan/Y-1372-2019
dc.authorwosidGüvenç, Tolga Sinan/AAK-6020-2020
dc.authorwosidÇELİK, AHMET/AAA-6615-2021
dc.contributor.authorGuvenc, Rengin Cetin
dc.contributor.authorGuevenc, Tolga Sinan
dc.contributor.authorTemizhan, Ahmet
dc.contributor.authorCavusuglu, Yueksel
dc.contributor.authorCelik, Ahmet
dc.contributor.authorYilmaz, Mehmet Birhan
dc.date.accessioned2024-05-19T14:42:17Z
dc.date.available2024-05-19T14:42:17Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractHypochloremia has recently gained interest as a potential marker of outcomes in patients with heart failure (HF). The exact pathophysiologic mechanism linking hypochloremia to HF is unclear but is thought to be mediated by chloride-sensitive proteins and channels located in kidneys. This analysis aimed to understand whether renal dysfunction (RD) affects the association of hypochloremia with mortality in patients with HF. Using data from a nationwide registry, 438 cases with complete data on serum chloride concentration and 1-year survival were included in the analysis. Patients with an estimated glomerular filtration rate of <60 mL/min/m(2) at baseline were accepted as having RD. Hypochloremia was defined as a chloride concentration <96 mEq/L at baseline. For HF patients without RD at baseline, patients with hypochloremia had a significantly higher 1-year all-cause mortality than those without hypochloremia (41.6% vs 13.0%, log-rank p < 0.001) and the association remained significant after multivariate adjustment (odds ratio (OR): 2.55, 95% confidence interval (CI): 1.25-5.21). The evidence supporting the association was very strong in this subgroup (Bayesian Factor (BF)(10): 48.25, log OR: 1.56, 95% CI: 0.69-2.43). For patients with RD at baseline, there was no statistically significant difference for 1-year mortality for patients with or without hypochloremia (36.3% vs 29.7, log-rank p = 0.35) and there was no evidence to support an association between hypochloremia and mortality (BF10: 1.18, log OR :0.66, 95% CI: -0.02 to 1.35). In patients with HF, the association between low chloride concentration and mortality is limited to those without RD at baseline.en_US
dc.identifier.doi10.1177/10815589221149186
dc.identifier.endpage349en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue4en_US
dc.identifier.pmid36680353en_US
dc.identifier.scopus2-s2.0-85150665900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org10.1177/10815589221149186
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5223
dc.identifier.volume71en_US
dc.identifier.wosWOS:000956447300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHeart Failureen_US
dc.subjectMortalityen_US
dc.subjectRenal Dysfunctionen_US
dc.subjectHypochloremiaen_US
dc.titleEffect of renal function on the prognostic importance of chloride in patients with heart failureen_US
dc.typeArticleen_US

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