Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip

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dc.authoridHaluk Çabuk / 0000-0002-1413-2149en_US
dc.authoridTaylan Bükülmez / 0000-0001-5996-2704
dc.authorscopusidHaluk Çabuk / 56400866300
dc.authorscopusidTaylan Bükülmez / 57194395788
dc.authorwosidTaylan Bükülmez / JKP-0858-2023
dc.authorwosidHaluk Çabuk / AAL-9654-2020
dc.contributor.authorAyanoğlu, Semih
dc.contributor.authorÇabuk, Haluk
dc.contributor.authorKuşku Çabuk, Fatmagül
dc.contributor.authorBeng, Kubilay
dc.contributor.authorYıldırım, Timur
dc.contributor.authorUyar Bozkurt, Süheyla
dc.date.accessioned2021-10-26T10:48:11Z
dc.date.available2021-10-26T10:48:11Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the number of relaxin receptors in the ligamentum teres and their role in causing DDH. Methods: We identified 26 infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody, and the amount of staining for relaxin receptors was determined using an ordinal H score. Results: The mean (SD) H scores of infants with DDH were significantly higher than those of controls: 215 (59) versus 52 (48); P = 0.00; 95% CI. Statistically significant difference between the two groups in terms of gender was not found. Conclusion: As a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH. Level of evidence: Level 2, Prospective comparative study.en_US
dc.identifier.citationAyanoğlu, S., Çabuk, H., Kuşku Çabuk, F., Beng, K., Yildirim, T., & Uyar Bozkurt, S. (2021). Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip. Journal of orthopaedic surgery and research, 16(1), 627. https://doi.org/10.1186/s13018-021-02784-wen_US
dc.identifier.doi10.1186/s13018-021-02784-wen_US
dc.identifier.issue627en_US
dc.identifier.pmid34663407en_US
dc.identifier.scopus2-s2.0-85117385364en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/s13018-021-02784-w
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2182
dc.identifier.volume16en_US
dc.identifier.wosWOS:000708501000012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇabuk, Haluk
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.ispartofJ Orthop Surg Res .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleGreater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hipen_US
dc.typeArticleen_US

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