Altered resting state functional connectivity and its correlation with cognitive functions at ultra high risk psychosis

Basit Öğe Kaydı
dc.authoridÇiğdem Ulaşoğlu-Yıldız / 0000-0003-1849-0055
dc.authorscopusidÇiğdem Ulaşoğlu-Yıldız / 57193497516
dc.authorwosidÇiğdem Ulaşoğlu-Yıldız / AGQ-4294-2022
dc.contributor.authorBülbül, Öznur
dc.contributor.authorKurt, Elif
dc.contributor.authorUlaşoğlu-Yıldız, Çiğdem
dc.contributor.authorDemiralp, Tamer
dc.contributor.authorÜçok, Alp
dc.date.accessioned2022-02-01T13:57:54Z
dc.date.available2022-02-01T13:57:54Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Sosyal Bilimler Enstitüsü, Psikoloji Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study is to identify robust resting state-functional connectivity (rs-FC) alterations and their correlations with the neuropsychological characteristics of Ultra-High Risk (UHR) for psychosis subjects compared to healthy controls (HCs). Twenty individuals with UHR and sixteen HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a cognitive battery evaluating attention, episodic memory and executive functions. Compared to HCs, UHR individuals showed working memory and set-shifting impairments. In functional connectivity (FC) analyses, the Default Mode Network (DMN) of the UHR subjects displayed increased FC with the visual areas and decreased FC with the Dorsal Attention Network (DAN). Additionally, the salience network (SN) of the UHR subjects displayed increased connectivity with wide posterior cortical areas in the temporal, parietal and occipital lobes, corresponding to posterior nodes of the SN itself, the Somato-Motor Network (SMN) and the DAN. The SN connectivity with the left SMN and DAN was positively correlated with the Trail Making Test - B scores of the UHR subjects. These findings show that the SN and DMN, which mostly show abnormal connectivity patterns in psychosis, are also affected in UHR subjects, while the SN plays a more central role with its hyperconnectivity to the DAN and SMN.en_US
dc.identifier.citationBulbul O, Kurt E, Ulasoglu-Yildiz C, Demiralp T, Ucok A. Altered resting state functional connectivity and its correlation with cognitive functions at ultra high risk psychosis. Psychiatry Res Neuroimaging. 2022 Jan 21;321:111444en_US
dc.identifier.doi10.1016/j.pscychresns.2022.111444en_US
dc.identifier.issn0925-4927en_US
dc.identifier.issn1872-7506en_US
dc.identifier.pmid35093807en_US
dc.identifier.scopus2-s2.0-85123642035en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2022.111444
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2449
dc.identifier.volume321en_US
dc.identifier.wosWOS:000754753700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlaşoğlu-Yıldız, Çiğdem
dc.language.isoenen_US
dc.relation.ispartofPsychiatry Res Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitive Functionen_US
dc.subjectFunctional Magnetic Resonance Imaging (fMRI)en_US
dc.subjectNeuroimagingen_US
dc.subjectResting Stateen_US
dc.subjectUltra High Risk Psychosis (UHR)en_US
dc.titleAltered resting state functional connectivity and its correlation with cognitive functions at ultra high risk psychosisen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
1-s2.0-S0925492722000051-main.pdf
Boyut:
3.99 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Psikoloji Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu