Intrauterine G-CSF administration in recurrent implantation failure (RIF): an rct

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dc.contributor.authorKalem Z.
dc.contributor.authorNamli Kalem M.
dc.contributor.authorBakirarar B.
dc.contributor.authorKent E.
dc.contributor.authorMakrigiannakis A.
dc.contributor.authorGurgan T.
dc.date.accessioned2020-08-30T20:01:33Z
dc.date.available2020-08-30T20:01:33Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study investigates the effects of intrauterine G-CSF on endometrial thickness, clinical pregnancy rate and live birth rate in a recurrent implantation failure (RIF) group with normal endometrium. This study was designed as a prospective randomized controlled trial with the involvement of 157 RIF group pati; ents. The RIF group was formed on the basis of the RIF criteria: “The failure to achieve a clinical pregnancy after the transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles to a woman under the age of 40 years. The study sample included 82 patients in the G-CSF group who received G-CSF once a day on hCG. The procedure was performed by administering 30 mIU of Leucostim®(Filgrastim [G-CSF] 30 mIU/mL; DEM Medical, Dong-A; South Korea) through slow infusion into the endometrial cavity using a soft embryo transfer catheter. Normal saline of 1 mL was infused into the endometrial cavity in the same way in 75 patients in the control group. The standard ICSI procedure was used for all patients, and fresh cycle embryos were transferred on the third or fifth day. No statistically significant difference was identified in clinical pregnancy rates, miscarriage rates and live birth rates between the G-CSF group and the control group (p = 0.112, p = 0.171, p = 0.644, respectively), and no difference was observed between the two groups regarding endometrial thickness (p = 0.965). The intervention of administration G-CSF into the uterine cavity in RIF patients with normal endometrium, did not alter the endometrial thickness, clinical pregnancy rates, or live birth rates. © 2020, The Author(s).en_US
dc.identifier.citationKalem, Z., Kalem, M. N., Bakirarar, B., Kent, E., Makrigiannakis, A., & Gurgan, T. (2020). Intrauterine G-CSF Administration in Recurrent Implantation Failure (RIF): An Rct. Scientific Reports, 10(1), 1-7.en_US
dc.identifier.doi10.1038/s41598-020-61955-7en_US
dc.identifier.issn2045-2322en_US
dc.identifier.issue1en_US
dc.identifier.pmid32198409en_US
dc.identifier.scopus2-s2.0-85082134746en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-020-61955-7
dc.identifier.urihttps://hdl.handle.net/20.500.12713/277
dc.identifier.volume10en_US
dc.identifier.wosWOS:000563415000016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKalem, Ziyaen_US
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIntrauterine G-CSF administration in recurrent implantation failure (RIF): an rcten_US
dc.typeArticleen_US

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