Packed Red Blood Cell Transfusion as a Predictor of Moderate-Severe Bronchopulmonary Dysplasia: A Comparative Cohort Study of Very Preterm Infants

Küçük Resim Yok



Dergi Başlığı

Dergi ISSN

Cilt Başlığı


Thieme Medical Publ Inc

Erişim Hakkı



Objective: Bronchopulmonary dysplasia (BPD) is a leading cause of morbidity and mortality in neonatal intensive care units. Our aim was to evaluate association between packed red blood cell transfusion and the development of BPD in very preterm infants. Study design: This retrospective study of very preterm infants (mean gestational age: 27.1 +/- 2.4 weeks, birth weight: 970 +/- 271 g) was conducted at Biruni University (Turkey) between July 2016 and December 2020. Results: BPD developed in 107 of the 246 enrolled neonates, including 47 (43.9%), 27 (25.3%), and 33 (30.8%) diagnosed with mild, moderate, and severe BPD, respectively. A total of 728 transfusions were administered. The increased number (4 transfusions [2-7] vs. 1 [1-3], p = 0.001) and volume of transfusions (75 mL/kg volume [40-130] vs. 20 [15-43], p = 0.001) were significantly higher in infants with BPD compared to those without BPD. The transfusion volume cut-off for the prediction of BPD by receiver operating characteristic curve analysis was 42 mL/kg (sensitivity 73.6%; specificity 75%; area under the receiver-operating characteristic curve: 0.82). In multivariate analysis, multiple transfusions and larger transfusion volume were independent risk factors for moderate-severe BPD. Conclusion: The increased number and volume of transfusions were associated with BPD in very preterm infants. A packed red blood cell transfusion volume >= 42 mL/kg was a statistically significant predictor of the development of BPD at a postmenstrual age of 36 weeks. Key points: center dot Transfusions were found to be an important risk factor for BPD development in very premature infants.. . center dot Number and volume of transfusion were associated with the severity of BPD. center dot Optimal cut point volume of transfusion for prediction of BPD was 42 mL/kg body weight.


Anahtar Kelimeler

Packed Red Blood Cell Transfusion, Bronchopulmonary Dysplasia, Risk Factor, Very Preterm


American Journal of Perinatology

WoS Q Değeri


Scopus Q Değeri