Packed Red Blood Cell Transfusion as a Predictor of Moderate-Severe Bronchopulmonary Dysplasia: A Comparative Cohort Study of Very Preterm Infants
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Thieme Medical Publ Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Bronchopulmonary dysplasia (BPD) is a leading cause of morbidity and mortality in neonatal intensive care units. Our aim was to evaluate association between packed red blood cell transfusion and the development of BPD in very preterm infants. Study design: This retrospective study of very preterm infants (mean gestational age: 27.1 +/- 2.4 weeks, birth weight: 970 +/- 271 g) was conducted at Biruni University (Turkey) between July 2016 and December 2020. Results: BPD developed in 107 of the 246 enrolled neonates, including 47 (43.9%), 27 (25.3%), and 33 (30.8%) diagnosed with mild, moderate, and severe BPD, respectively. A total of 728 transfusions were administered. The increased number (4 transfusions [2-7] vs. 1 [1-3], p = 0.001) and volume of transfusions (75 mL/kg volume [40-130] vs. 20 [15-43], p = 0.001) were significantly higher in infants with BPD compared to those without BPD. The transfusion volume cut-off for the prediction of BPD by receiver operating characteristic curve analysis was 42 mL/kg (sensitivity 73.6%; specificity 75%; area under the receiver-operating characteristic curve: 0.82). In multivariate analysis, multiple transfusions and larger transfusion volume were independent risk factors for moderate-severe BPD. Conclusion: The increased number and volume of transfusions were associated with BPD in very preterm infants. A packed red blood cell transfusion volume >= 42 mL/kg was a statistically significant predictor of the development of BPD at a postmenstrual age of 36 weeks. Key points: center dot Transfusions were found to be an important risk factor for BPD development in very premature infants.. . center dot Number and volume of transfusion were associated with the severity of BPD. center dot Optimal cut point volume of transfusion for prediction of BPD was 42 mL/kg body weight.
Açıklama
Anahtar Kelimeler
Packed Red Blood Cell Transfusion, Bronchopulmonary Dysplasia, Risk Factor, Very Preterm
Kaynak
American Journal of Perinatology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
