Packed Red Blood Cell Transfusion as a Predictor of Moderate-Severe Bronchopulmonary Dysplasia: A Comparative Cohort Study of Very Preterm Infants

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dc.authoridBOLAT, Fatih/0000-0002-8363-2139
dc.authorwosidBOLAT, Fatih/ABP-7488-2022
dc.contributor.authorBolat, Fatih
dc.contributor.authorDursun, Mesut
dc.contributor.authorSariaydin, Mehmet
dc.date.accessioned2024-05-19T14:46:08Z
dc.date.available2024-05-19T14:46:08Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: Bronchopulmonary dysplasia (BPD) is a leading cause of morbidity and mortality in neonatal intensive care units. Our aim was to evaluate association between packed red blood cell transfusion and the development of BPD in very preterm infants. Study design: This retrospective study of very preterm infants (mean gestational age: 27.1 +/- 2.4 weeks, birth weight: 970 +/- 271 g) was conducted at Biruni University (Turkey) between July 2016 and December 2020. Results: BPD developed in 107 of the 246 enrolled neonates, including 47 (43.9%), 27 (25.3%), and 33 (30.8%) diagnosed with mild, moderate, and severe BPD, respectively. A total of 728 transfusions were administered. The increased number (4 transfusions [2-7] vs. 1 [1-3], p = 0.001) and volume of transfusions (75 mL/kg volume [40-130] vs. 20 [15-43], p = 0.001) were significantly higher in infants with BPD compared to those without BPD. The transfusion volume cut-off for the prediction of BPD by receiver operating characteristic curve analysis was 42 mL/kg (sensitivity 73.6%; specificity 75%; area under the receiver-operating characteristic curve: 0.82). In multivariate analysis, multiple transfusions and larger transfusion volume were independent risk factors for moderate-severe BPD. Conclusion: The increased number and volume of transfusions were associated with BPD in very preterm infants. A packed red blood cell transfusion volume >= 42 mL/kg was a statistically significant predictor of the development of BPD at a postmenstrual age of 36 weeks. Key points: center dot Transfusions were found to be an important risk factor for BPD development in very premature infants.. . center dot Number and volume of transfusion were associated with the severity of BPD. center dot Optimal cut point volume of transfusion for prediction of BPD was 42 mL/kg body weight.en_US
dc.identifier.doi10.1055/a-2051-8245
dc.identifier.issn0735-1631
dc.identifier.issn1098-8785
dc.identifier.pmid36898407en_US
dc.identifier.scopus2-s2.0-85161057488en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1055/a-2051-8245
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5452
dc.identifier.wosWOS:000967604200007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofAmerican Journal of Perinatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPacked Red Blood Cell Transfusionen_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectRisk Factoren_US
dc.subjectVery Pretermen_US
dc.titlePacked Red Blood Cell Transfusion as a Predictor of Moderate-Severe Bronchopulmonary Dysplasia: A Comparative Cohort Study of Very Preterm Infantsen_US
dc.typeArticleen_US

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