Effect of visible light on vasospasticity of post-subarachnoid hemorrhage cerebrospinal fluid

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dc.authoridTalat Kırış / 0000-0002-2985-3758
dc.authorscopusidTalat Kırış / 6602747157
dc.authorwosidTalat Kırış / AAP-4665-2020
dc.contributor.authorSabancı, Pulat Akın
dc.contributor.authorOmay, Bülent
dc.contributor.authorAras, Yavuz
dc.contributor.authorAydöşeli, Aydın
dc.contributor.authorAli, Ahmet
dc.contributor.authorErdem, Tülin
dc.contributor.authorSencer, Altay
dc.contributor.authorKırış, Talat
dc.date.accessioned2020-08-30T20:08:00Z
dc.date.available2020-08-30T20:08:00Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Objective Cerebral vasospasm (CV) is a serious complication of subarachnoid hemorrhage (SAH) with high morbidity and mortality rates. The mechanism of CV has not been determined. There are many theories related to this unsolved issue, one of which supports CV as a two-stage phenomenon from a pathophysiologic perspective. The first stage consists of inhibition of neuronal nitric oxide synthase by oxyhemoglobin, which results in a decrease of nitric oxide (NO) production. The second stage consists of an increase in the levels of asymmetric dimethylarginine through bilirubin oxidation products (BOXes), which are oxidized by-products of hemoglobin metabolism. These in turn inhibit endothelial nitric oxide synthase (eNOS), which results in the blockage of the second NO production mechanism. BOXes are sensitive to visible light, as is their precursor bilirubin. The hypothesis of CV prevention using the photosensitivity of BOXes was tested in this study. Material and Methods Cerebrospinal fluid (CSF) obtained from two patients with SAH was divided in half and either exposed to a standard dose of visible light or not exposed to any light. The CSF was spectrophotometrically investigated and the concentration of BOXes was measured. A comparison between CSF samples exposed to light and not exposed to light was made. Using two groups of 16 rats each, the vasospastic effect of the CSF exposed and not exposed to light on arteries of the cortical surface was measured. The cortex was exposed using the cranial window. Results Spectrophotometric analysis revealed that the concentration of BOXes in the CSF decreased significantly after being exposed to visible light ( p <0.001). There was a significant difference of the vasospastic effect of CSF on exposed cortical arteries ( p <0.001). Conclusion The concentration of BOXes and the vasospastic effect of CSF taken from patients with SAH were significantly reduced after being exposed to visible light if compared with CSF not exposed to light.en_US
dc.identifier.citationSabanci, P. A., Omay, B., Aras, Y., Aydoseli, A., Ali, A., Erdem, T., ... & Kiris, T. (2017). Effect of Visible Light on Vasospasticity of Post–Subarachnoid Hemorrhage Cerebrospinal Fluid. Journal of Neurological Surgery Part A: Central European Neurosurgery, 78(06), 548-555.en_US
dc.identifier.doi10.1055/s-0036-1594005en_US
dc.identifier.endpage555en_US
dc.identifier.issn2193-6315en_US
dc.identifier.issn2193-6323en_US
dc.identifier.issue6en_US
dc.identifier.pmid28597450en_US
dc.identifier.scopus2-s2.0-85020702114en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage548en_US
dc.identifier.urihttps://doi.org/10.1055/s-0036-1594005
dc.identifier.urihttps://hdl.handle.net/20.500.12713/868
dc.identifier.volume78en_US
dc.identifier.wosWOS:000412518000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKırış, Talaten_US
dc.language.isoenen_US
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofJournal of Neurological Surgery Part A-Central European Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectCerebral Vasospasmen_US
dc.subjectPhotosensitivityen_US
dc.subjectCsfen_US
dc.subjectBoxen_US
dc.titleEffect of visible light on vasospasticity of post-subarachnoid hemorrhage cerebrospinal fluiden_US
dc.typeArticleen_US

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