Neuroprotective Effects of Niacin on Ischemia/Reperfusion Injury of the Rabbit Spinal Cord
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
-OBJECTIVE: Previous studies have shown niacin has neuroprotective effects on the central nervous system. However, its specific effect on spinal cord ischemia/ reperfusion injury has not yet been explored. This study aims to evaluate whether niacin can contribute neuro-protective effects on spinal cord ischemia/reperfusion injury. -METHODS: Rabbits were randomized into 4 groups of 8 animals: group I (control), group II (ischemia), group III (30 mg/kg methylprednisolone, intraperitoneal), and group IV (500 mg/kg niacin, intraperitoneal). The rabbits in group IV were premedicated with niacin for 7 days prior to inducing ischemia/reperfusion injury. The control group was subjected only to a laparotomy, while the remaining groups underwent spinal cord ischemia through a 20-minute occlusion of the aorta caudal to the left renal ar-tery. Following the procedure, levels of catalase, malon-dialdehyde, xanthine oxidase, myeloperoxidase, and caspase-3 were analyzed. Ultrastructural, histopatholog-ical, and neurological evaluations were also performed. -RESULTS: Spinal cord ischemia/reperfusion injury resulted in increased levels of xanthine oxidase, malon-dialdehyde, myeloperoxidase, and caspase-3, with a concomitant decrease in catalase levels. Treatment with methylprednisolone and niacin led to decreased levels of xanthine oxidase, malondialdehyde, myeloperoxidase, and caspase-3 and an increase in catalase. Both methylpred-n isolone and niacin treatments demonstrated improve-ments in histopathological, ultrastructural, and neurological assessments. -CONCLUSIONS: Our findings suggest that niacin has antiapoptotic, anti-inflammatory, antioxidant, and neuro-protective effects at least equal to methylprednisolone in ischemia/reperfusion injury of the spinal cord. This study is the first to report the neuroprotective impact of niacin on spinal cord ischemia/reperfusion injury. Further research is warranted to elucidate the role of niacin in this context.
Açıklama
Anahtar Kelimeler
Ischemia/Reperfusion, Methylprednisolone, Neuroprotection, Niacin, Spinal Cord
Kaynak
World Neurosurgery
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
177
