Neuroprotective Effects of Niacin on Ischemia/Reperfusion Injury of the Rabbit Spinal Cord

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dc.authoridGurer, Bora/0000-0003-1500-6184
dc.authoridERMUTLU, ILCIM/0000-0003-0234-5697
dc.authorwosidGurer, Bora/K-1177-2012
dc.contributor.authorErmutlu, Ilcim
dc.contributor.authorFesli, Ramazan
dc.contributor.authorArikok, Ata Turker
dc.contributor.authorErguder, Berrin Imge
dc.contributor.authorKertmen, Hayri
dc.contributor.authorGurer, Bora
dc.date.accessioned2024-05-19T14:42:53Z
dc.date.available2024-05-19T14:42:53Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstract-OBJECTIVE: Previous studies have shown niacin has neuroprotective effects on the central nervous system. However, its specific effect on spinal cord ischemia/ reperfusion injury has not yet been explored. This study aims to evaluate whether niacin can contribute neuro-protective effects on spinal cord ischemia/reperfusion injury. -METHODS: Rabbits were randomized into 4 groups of 8 animals: group I (control), group II (ischemia), group III (30 mg/kg methylprednisolone, intraperitoneal), and group IV (500 mg/kg niacin, intraperitoneal). The rabbits in group IV were premedicated with niacin for 7 days prior to inducing ischemia/reperfusion injury. The control group was subjected only to a laparotomy, while the remaining groups underwent spinal cord ischemia through a 20-minute occlusion of the aorta caudal to the left renal ar-tery. Following the procedure, levels of catalase, malon-dialdehyde, xanthine oxidase, myeloperoxidase, and caspase-3 were analyzed. Ultrastructural, histopatholog-ical, and neurological evaluations were also performed. -RESULTS: Spinal cord ischemia/reperfusion injury resulted in increased levels of xanthine oxidase, malon-dialdehyde, myeloperoxidase, and caspase-3, with a concomitant decrease in catalase levels. Treatment with methylprednisolone and niacin led to decreased levels of xanthine oxidase, malondialdehyde, myeloperoxidase, and caspase-3 and an increase in catalase. Both methylpred-n isolone and niacin treatments demonstrated improve-ments in histopathological, ultrastructural, and neurological assessments. -CONCLUSIONS: Our findings suggest that niacin has antiapoptotic, anti-inflammatory, antioxidant, and neuro-protective effects at least equal to methylprednisolone in ischemia/reperfusion injury of the spinal cord. This study is the first to report the neuroprotective impact of niacin on spinal cord ischemia/reperfusion injury. Further research is warranted to elucidate the role of niacin in this context.en_US
dc.identifier.doi10.1016/j.wneu.2023.06.117
dc.identifier.endpageE656en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid37400055en_US
dc.identifier.scopus2-s2.0-85166287118en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE644en_US
dc.identifier.urihttps://doi.org10.1016/j.wneu.2023.06.117
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5297
dc.identifier.volume177en_US
dc.identifier.wosWOS:001076131400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectMethylprednisoloneen_US
dc.subjectNeuroprotectionen_US
dc.subjectNiacinen_US
dc.subjectSpinal Corden_US
dc.titleNeuroprotective Effects of Niacin on Ischemia/Reperfusion Injury of the Rabbit Spinal Corden_US
dc.typeArticleen_US

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