Neuroprotective Effects of Niacin on Ischemia/Reperfusion Injury of the Rabbit Spinal Cord
dc.authorid | Gurer, Bora/0000-0003-1500-6184 | |
dc.authorid | ERMUTLU, ILCIM/0000-0003-0234-5697 | |
dc.authorwosid | Gurer, Bora/K-1177-2012 | |
dc.contributor.author | Ermutlu, Ilcim | |
dc.contributor.author | Fesli, Ramazan | |
dc.contributor.author | Arikok, Ata Turker | |
dc.contributor.author | Erguder, Berrin Imge | |
dc.contributor.author | Kertmen, Hayri | |
dc.contributor.author | Gurer, Bora | |
dc.date.accessioned | 2024-05-19T14:42:53Z | |
dc.date.available | 2024-05-19T14:42:53Z | |
dc.date.issued | 2023 | |
dc.department | İstinye Üniversitesi | en_US |
dc.description.abstract | -OBJECTIVE: Previous studies have shown niacin has neuroprotective effects on the central nervous system. However, its specific effect on spinal cord ischemia/ reperfusion injury has not yet been explored. This study aims to evaluate whether niacin can contribute neuro-protective effects on spinal cord ischemia/reperfusion injury. -METHODS: Rabbits were randomized into 4 groups of 8 animals: group I (control), group II (ischemia), group III (30 mg/kg methylprednisolone, intraperitoneal), and group IV (500 mg/kg niacin, intraperitoneal). The rabbits in group IV were premedicated with niacin for 7 days prior to inducing ischemia/reperfusion injury. The control group was subjected only to a laparotomy, while the remaining groups underwent spinal cord ischemia through a 20-minute occlusion of the aorta caudal to the left renal ar-tery. Following the procedure, levels of catalase, malon-dialdehyde, xanthine oxidase, myeloperoxidase, and caspase-3 were analyzed. Ultrastructural, histopatholog-ical, and neurological evaluations were also performed. -RESULTS: Spinal cord ischemia/reperfusion injury resulted in increased levels of xanthine oxidase, malon-dialdehyde, myeloperoxidase, and caspase-3, with a concomitant decrease in catalase levels. Treatment with methylprednisolone and niacin led to decreased levels of xanthine oxidase, malondialdehyde, myeloperoxidase, and caspase-3 and an increase in catalase. Both methylpred-n isolone and niacin treatments demonstrated improve-ments in histopathological, ultrastructural, and neurological assessments. -CONCLUSIONS: Our findings suggest that niacin has antiapoptotic, anti-inflammatory, antioxidant, and neuro-protective effects at least equal to methylprednisolone in ischemia/reperfusion injury of the spinal cord. This study is the first to report the neuroprotective impact of niacin on spinal cord ischemia/reperfusion injury. Further research is warranted to elucidate the role of niacin in this context. | en_US |
dc.identifier.doi | 10.1016/j.wneu.2023.06.117 | |
dc.identifier.endpage | E656 | en_US |
dc.identifier.issn | 1878-8750 | |
dc.identifier.issn | 1878-8769 | |
dc.identifier.pmid | 37400055 | en_US |
dc.identifier.scopus | 2-s2.0-85166287118 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | E644 | en_US |
dc.identifier.uri | https://doi.org10.1016/j.wneu.2023.06.117 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12713/5297 | |
dc.identifier.volume | 177 | en_US |
dc.identifier.wos | WOS:001076131400001 | en_US |
dc.identifier.wosquality | N/A | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.relation.ispartof | World Neurosurgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.snmz | 20240519_ka | en_US |
dc.subject | Ischemia/Reperfusion | en_US |
dc.subject | Methylprednisolone | en_US |
dc.subject | Neuroprotection | en_US |
dc.subject | Niacin | en_US |
dc.subject | Spinal Cord | en_US |
dc.title | Neuroprotective Effects of Niacin on Ischemia/Reperfusion Injury of the Rabbit Spinal Cord | en_US |
dc.type | Article | en_US |