Gut microbiota-derived metabolite trimethylamine N-oxide and biomarkers of inflammation are linked to endothelial and coronary microvascular function in patients with inflammatory bowel disease

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dc.authoridTolga Sinan Güvenç / 0000-0002-6738-266Xen_US
dc.authorscopusidTolga Sinan Güvenç / 6602421975en_US
dc.authorwosidTolga Sinan Güvenç / JQN-5460-2023
dc.contributor.authorKul, Sere
dc.contributor.authorCaliskan, Zuhal
dc.contributor.authorGüvenç, Tolga Sinan
dc.contributor.authorCelik, Fatma Betul
dc.contributor.authorSarmis, Abdurrahman
dc.contributor.authorAtici, Adem
dc.date.accessioned2022-12-19T07:17:51Z
dc.date.available2022-12-19T07:17:51Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Inflammatory bowel disease (IBD), which is an umbrella term used for ulcerative colitis (UC) and Crohn's disease (CD), is associated with an increased risk for atherosclerotic cardiovascular disease (CVD). We aimed to investigate the association of local and systemic biomarkers of inflammation and gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) with endothelial and coronary microvascular dysfunction in IBD. Methods: A total of 56 patients with IBD (20 with UC and 36 with CD) and 34 age and gender matched controls were included. For all participants, samples were collected to analyze faecal calprotectin, and TMAO concentrations. Ultrasound-based examinations were done to measure flow-mediated vasodilatation (FMD) and coronary flow velocity reserve (CFVR). Results: Patients with IBD had lower CFVR (2.07 (1.82–2.40)) and FMD (8.7 ± 3.7) as compared to controls (2.30 (2.07–2.74), p = 0.005 and 11.9 ± 6.8, p = 0.03). In patients with IBD, TMAO concentration (r = ?0.30, p = 0.03), C-reactive protein (r = ?0.29, p = 0.03) and WBC count (r = ?0.37, p = 0.006) had a significant negative correlation with CFVR, and TMAO (? = ?0.27, 95 % CI: ?0.23 to ?0.02) and WBC count (? = ?0.31, 95 % CI: ?0.56 to ?0.06) were significant predictors of CFVR after multivariate adjustment. None of the biomarkers of inflammation or TMAO showed significant correlations with FMD. In patients with UC, TMAO showed a significant correlation with both CFVR (r = ?0.55, p = 0.01) and FMD (r = ?0.60, p = 0.005) while only WBC count had a statistically significant correlation with CFVR (r = ?0.49, p = 0.004) in patients with CD. Conclusions: Gut microbiota-derived metabolite TMAO and biomarkers of systemic inflammation are associated with measures of endothelial/coronary microvascular dysfunction in patients with IBD. © 2022en_US
dc.identifier.citationKul, S., Caliskan, Z., Guvenc, T. S., Celik, F. B., Sarmis, A., Atici, A., ... & Caliskan, M. (2022). Gut microbiota-derived metabolite trimethylamine N-oxide and biomarkers of inflammation are linked to endothelial and coronary microvascular function in patients with inflammatory bowel disease. Microvascular Research, 104458.en_US
dc.identifier.doi10.1016/j.mvr.2022.104458en_US
dc.identifier.isbn00262862
dc.identifier.scopus2-s2.0-85143331922en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.mvr.2022.104458
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3607
dc.identifier.volume146en_US
dc.identifier.wosWOS:000989207000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüvenç, Tolga Sinan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrovascular Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Microvascular Mysfunctionen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectGut Microbiomeen_US
dc.subjectInflammationen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.titleGut microbiota-derived metabolite trimethylamine N-oxide and biomarkers of inflammation are linked to endothelial and coronary microvascular function in patients with inflammatory bowel diseaseen_US
dc.typeArticleen_US

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