Bioengineered Ionic Liquid for Catheter-Directed Tissue Ablation, Drug Delivery, and Embolization

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dc.authoridOklu, Rahmi/0000-0003-4984-1778
dc.contributor.authorKeum, Hyeongseop
dc.contributor.authorAlbadawi, Hassan
dc.contributor.authorZhang, Zefu
dc.contributor.authorGraf, Erin
dc.contributor.authorDos Santos, Pedro Reck
dc.contributor.authorGunduz, Seyda
dc.contributor.authorOklu, Rahmi
dc.date.accessioned2024-05-19T14:39:00Z
dc.date.available2024-05-19T14:39:00Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDelivery of therapeutics to solid tumors with high bioavailability remains a challenge and is likely the main contributor to the ineffectiveness of immunotherapy and chemotherapy. Here, a catheter-directed ionic liquid embolic (ILE) is bioengineered to achieve durable vascular embolization, uniform tissue ablation, and drug delivery in non-survival and survival porcine models of embolization, outperforming the clinically used embolic agents. To simulate the clinical scenario, rabbit VX2 orthotopic liver tumors are treated showing successful trans-arterial delivery of Nivolumab and effective tumor ablation. Furthermore, similar results are also observed in human ex vivo tumor tissue as well as significant susceptibility of highly resistant patient-derived bacteria is seen to ILE, suggesting that ILE can prevent abscess formation in embolized tissue. ILE represents a new class of liquid embolic agents that can treat tumors, improve the delivery of therapeutics, prevent infectious complications, and potentially increase chemo- and immunotherapy response in solid tumors.en_US
dc.description.sponsorshipNational Institutes of Health; Mayo Clinic Clinician Investigator Award; Christian Haub Family Career Development Award; [R01CA257558]; [R01HL140951]; [R01DK130566]; [R01HL165176]; [R01HL137193]en_US
dc.description.sponsorshipR.O. gratefully acknowledges funding from the National Institutes of Health (R01CA257558, R01HL140951, R01DK130566, R01HL165176, and R01HL137193) and the Mayo Clinic Clinician Investigator Award. H.A. acknowledges funding from the Christian Haub Family Career Development Award. The authors thank N. M. Gades D.V.M. for veterinary assistance, and F. M. Yurtsever Ph.D. for assistance with Figure 1a. The illustrations in the figures were created with BioRender.com.en_US
dc.identifier.doi10.1002/adma.202309412
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.pmid38305472en_US
dc.identifier.scopus2-s2.0-85185105333en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1002/adma.202309412
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4675
dc.identifier.wosWOS:001163095700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofAdvanced Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAngiographyen_US
dc.subjectDeliveryen_US
dc.subjectEmbolizationen_US
dc.subjectImmunotherapyen_US
dc.subjectLarge Animal Modelsen_US
dc.titleBioengineered Ionic Liquid for Catheter-Directed Tissue Ablation, Drug Delivery, and Embolizationen_US
dc.typeArticleen_US

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