Differential interactome proposes subtype-specific biomarkers and potential therapeutics in renal cell carcinomas
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Abstract: Although many studies have been conducted on single gene therapies in cancer patients, the reality is that tumor arises from different coordinating protein groups. Unveiling perturbations in protein interactome related to the tumor formation may contribute to the development of effective diagnosis, treatment strategies, and prognosis. In this study, considering the clinical and transcriptome data of three Renal Cell Carcinoma (RCC) subtypes (ccRCC, pRCC, and chRCC) retrieved from The Cancer Genome Atlas (TCGA) and the human protein interactome, the differential protein–protein interactions were identified in each RCC subtype. The approach enabled the identification of differentially interacting proteins (DIPs) indicating prominent changes in their interaction patterns during tumor formation. Further, diagnostic and prognostic performances were generated by taking into account DIP clusters which are specific to the relevant subtypes. Furthermore, considering the mesenchymal epithelial transition (MET) receptor tyrosine kinase (PDB ID: 3DKF) as a potential drug target specific to pRCC, twenty-one lead compounds were identified through virtual screening of ZINC molecules. In this study, we presented remarkable findings in terms of early diagnosis, prognosis, and effective treatment strategies, that deserve further experimental and clinical efforts.
Açıklama
Anahtar Kelimeler
Renal Cancers, Protein Interactome, Diagnostic Biomarker, Prognostic Biomarker, Virtual Screening, Docking
Kaynak
J. Pers. Med.
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
11
Sayı
158
Künye
Caliskan, A.; Gulfidan, G.;
Sinha, R.; Arga, K.Y. Differential
Interactome Proposes Subtype-Specific
Biomarkers and Potential Therapeutics
in Renal Cell Carcinomas. J. Pers. Med.
2021, 11, 158. https://doi.org/10.3390/jpm11020158
