Dynamic thiol/disulfide homeostasis in predicting adverse neonatal outcomes in fetal growth restriction

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dc.authoridBaşak Gümüş Güler / 0000-0002-0182-6774
dc.authorscopusidBaşak Gümüş Güler / 57193546825
dc.authorwosidBaşak Gümüş Güler / JHA-5039-2023
dc.contributor.authorÖzler, Sibel
dc.contributor.authorÖztaş, Efser
dc.contributor.authorGümüş Güler, Başak
dc.contributor.authorErel, Özcan
dc.contributor.authorÇağlar, Ali Turhan
dc.contributor.authorErgin, Merve
dc.contributor.authorDanışman, Nuri
dc.date.accessioned2020-08-30T20:06:41Z
dc.date.available2020-08-30T20:06:41Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractAim: The main aim of this study was to investigate thiol/disulfide homeostasis associated with fetal growth restriction (FGR) and to evaluate whether alterations are predictive for adverse neonatal outcomes. Methods: 273 pregnant women (77 with FGR and 196 with normal fetal growth) were enrolled in this prospective case-control study. Results: Native thiol and total thiol were decreased in FGR compared to the control group (p < .001; p < .001). Decreased levels of maternal serum native and total thiol were significantly associated with adverse neonatal outcomes in FGR (OR: 0.983, 95% CI 0.976-0.991, p < .001; OR: 0.983, 95% CI 0.976-0.991, p < .001). Decreased maternal serum total thiol levels were the only significantly associated risk factor with adverse neonatal outcomes in FGR (OR: 0.981, 95% CI 0.963-1.000, p = .046). Conclusion: The decrease in the antioxidants of thiol/disulfide mechanism may be related to the development of both FGR and adverse neonatal outcome in FGR.en_US
dc.identifier.citationOzler, S., Oztas, E., Guler, B. G., Erel, O., Caglar, A. T., Ergin, M., & Danisman, N. (2020). Dynamic thiol/disulfide homeostasis in predicting adverse neonatal outcomes in fetal growth restriction. Fetal and Pediatric Pathology, 39(2), 132-144.en_US
dc.identifier.doi10.1080/15513815.2019.1644686en_US
dc.identifier.endpage144en_US
dc.identifier.issn1551-3815en_US
dc.identifier.issn1551-3823en_US
dc.identifier.issue2en_US
dc.identifier.pmid31362586en_US
dc.identifier.scopus2-s2.0-85075514866en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1080/15513815.2019.1644686
dc.identifier.urihttps://hdl.handle.net/20.500.12713/591
dc.identifier.volume39en_US
dc.identifier.wosWOS:000479402300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGümüş Güler, Başaken_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofFetal and Pediatric Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFetal Growth Restrictionen_US
dc.subjectDynamic Thiol Disulfide Homeostasisen_US
dc.subjectAdverse Neonatal Outcomesen_US
dc.titleDynamic thiol/disulfide homeostasis in predicting adverse neonatal outcomes in fetal growth restrictionen_US
dc.typeArticleen_US

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